Use of Carotid Ultrasound to Identify Subclinical Vascular Disease and Evaluate Cardiovascular Disease Risk: A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the Society for Vascular Medicine

Stein, James H.; Korcarz, Claudia E.; Hurst, R. Todd; Lonn, Eva; Kendall, Christopher; Mohler, Emile R.; Najjar, Samer S.; Rembold, Christopher M.; Post, Wendy S.

doi:10.1016/j.echo.2007.11.011

Cited by 2,011 publications

(1,785 citation statements)

References 94 publications

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“…Moreover, some surrogate biomarkers may prove useful for ruling out the presence of asymptomatic cardiac disease, such as natriuretic peptides, as well as some non-invasive cardiac investigations, such as ECG and echocardiography and carotid ultrasound [17,26,[149][150][151]. Other standard laboratory tests may be useful in ruling out the presence of renal dysfunction, anemia, diabetes mellitus, or hepatic diseases.…”

Section: Future Perspectivesmentioning

confidence: 99%

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

Clerico

Zaninotto

Ripoli

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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According to recent international guidelines, including the 2012 Third Universal Definiton of Myocardial Infarction by the Joint ESC/ACCF/AHA/WHF Task Force, an increase in cardiac troponin (cTn) levels over the 99th percentile upper reference limit (99th URL) should be considered clinically relevant, this cut-off being measured with an imprecision ≤10 CV%. In theory 99th URL values strongly depend not only on demographic and physiological variables (i.e. criteria for considering the reference population "healthy"), but also on the analytical performance of cTn methods and mathematical algorithms used for the calculation. The aim of the present article was therefore to review the methodological and pathophysiological factors affecting the evaluation and calculation of the 99th URL for cTn assay. The critical analysis made showed that no uniform procedure is followed, and nor have experts or regulatory bodies provided uniform guidelines for researchers or cTn assays manufacturers as an aid in "their quest to define normality". In particular, little attention has been paid to the way in which a healthy reference population is to be selected, or the criteria for calculating the 99th URL value for cTn assays, thus highlighting the need for international recommendations not only for demographic and physiological variables criteria for defining a healthy reference population, but also for calculating mathematical algorithms for establishing/ calculating clinical decision values. An expert consensus group, comprising laboratory and clinical scientists, biomedical statisticians, industrial and regulatory representatives, should be responsible for drawing up these guidelines.

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Section: Future Perspectivesmentioning

confidence: 99%

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

Clerico

Zaninotto

Ripoli

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…[52] тричі з розрахунком середнього значен-ня почергово в правій та лівій сонній артерії. Окрім того, визначали максимальну величину ТКІМ (ТКІМмакс).…”

Section: клінічні дослідження / Clinicial Researchesunclassified

Порівняння Впливу Фіксованої Комбінації Периндоприл/Амлодипін На Ураження Органів-Мішеней У Пацієнтів З Артеріальною Гіпертензією З ішемічною Хворобою Серця Та Без Неї (Результати Дослідження EPHES)

Radchenko

Mushtenko

Torbas

et al. 2022

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“…The right common carotid artery proximal to the bulb was imaged in multiple longitudinal planes for the best resolution of the CIMT of the far wall. CIMT was defined as the distance between the leading edge of the lumen intimal interface and the leading edge of the media adventitia interface of the far wall, measured in end diastole, 1 cm proximal to the bifurcation (8). All examinations were performed by the same experienced investigator (intraobserver variability: r =0.979).…”

Section: Carotid Artery Ultrasoundmentioning

confidence: 99%

“…In detail, carotid artery intima-media thickness (CIMT) may be accurately measured by ultrasound (8), and it is now widely used as an early marker for atherosclerosis (9,10). Indeed, IMT values are predictive of CV events and stroke in individuals without a clinically evident disease (9).…”

Section: Introductionmentioning

confidence: 99%

Preclinical atherosclerosis in patients with inflammatory bowel diseases: a case-control study

Bruzzese

Palermo

Lorenzetti

et al. 2017

Annals of Translational Medicine

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Background: An independent role of chronic inflammation in the atherosclerotic process in patients with inflammatory bowel diseases (IBD) has been suggested, but data are still contentious. We assessed preclinical atherosclerosis in the IBD patients without traditional risk factors. Methods:In this case-control study we assessed the early atherosclerotic alterations by carotid artery intima-media thickness (CIMT) measurement in IBD patients and matched controls. The normal CIMT values were ≤0.9 mm; moderate thickness when >0.9 and ≤1.2 mm, and pre-clinical atherosclerosis when >1.2 mm. We selected a homogeneous group of IBD patients, all in ongoing biologic therapy, without any traditional risk factor for atherosclerosis as well as controls. Conclusions: This case-control study found that the atherosclerotic process is not more apparent in IBD patients without traditional risk factors.

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Use of Carotid Ultrasound to Identify Subclinical Vascular Disease and Evaluate Cardiovascular Disease Risk: A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the Society for Vascular Medicine

Cited by 2,011 publications

References 94 publications

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

Preclinical atherosclerosis in patients with inflammatory bowel diseases: a case-control study

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