Use of Cardiovascular Drugs in an Older Swedish Population

Wills, Phillippa; Fastbom, Johan; Claesson, Cecilia B.; Cornelius, Christel; Thorslund, Mats; Winblad, Bengt

doi:10.1111/j.1532-5415.1996.tb05638.x

Cited by 21 publications

(14 citation statements)

References 19 publications

(53 reference statements)

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“…Indobufen and ticlopidine are usually associated with diarrhea [26,27] and the apparent relationship with constipation is not easily explained by their known pharmacological mechanism of action [28] . Although the association between calcium antagonists and constipation did not reach the level of statistical significance, it is consistent with the notion that constipation is a possible adverse event of these drugs [29] . No data are available in literature assessing relationship between digoxine and constipation.…”

Section: Characteristics Of Neurological Lesions and Gi Symptomssupporting

confidence: 69%

Chronic constipation in hemiplegic patients

Bracci

Badiali

Pezzotti

et al. 2007

WJG

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Section: Characteristics Of Neurological Lesions and Gi Symptomssupporting

confidence: 69%

Chronic constipation in hemiplegic patients

Bracci

Badiali

Pezzotti

et al. 2007

WJG

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“…There are few population-based studies of cardiovascular drug treatments in people older than 75 years of age and of those elderly who live outside institutions [6,8]. The development has been rapid during the 1990s in the treatment of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 98%

Use of cardiovascular drugs by home-dwelling coronary patients aged 75 years and older

Strandberg

Pitkälä

Kulp

et al. 2001

European Journal of Clinical Pharmacology

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“…48 Information on medication use was collected for the 2 weeks preceding the baseline interview. 49 Use of both prescription and nonprescription drugs was queried, and medicine containers and prescription forms were inspected to verify this information. Antihypertensive drugs included all medicines potentially used for lowering blood pressure (Anatomical Therapeutic Chemical classification system 50 …”

Section: Assessment Of Other Covariatesmentioning

confidence: 99%

Incidence of Dementia in Relation to Stroke and the Apolipoprotein E ε4 Allele in the Very Old

Zhu

Fratiglioni

Guo

et al. 2000

Stroke

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Background and Purpose-Both stroke and the apolipoprotein E (APOE) ⑀4 allele increase the risk of dementia. However, the interaction between stroke and APOE on dementia is still unclear. We addressed this topic by using a longitudinal design. Methods-We followed up a community cohort of 1301 subjects aged Ն75 years, who did not have dementia at baseline.Among them, 92 subjects had a history of stroke (from 3 months to 16 years before baseline interview). After the 3-year follow-up, 224 dementia cases had been diagnosed. During the period of follow-up, 91 subjects had a first occurrence of stroke (incident stroke). The APOE genotype was known for 985 subjects. Cox proportional hazards regression models were constructed to estimate the risk for dementia in terms of relative risks (RRs) for stroke and the APOE ⑀4 allele, with adjustment for age, sex, education, systolic blood pressure, antihypertensive medication use, and heart disease. Results-In the entire study population, RRs for dementia related to history of stroke and incident stroke were 1.7 (95% CI, 1.1 to 2.6) and 2.4 (95% CI, 1.6 to 3.5), respectively, after adjustment for all potential confounders. Subjects with stroke that occurred within 3 years before baseline had RR of 2.4 (95% CI, 1.4 to 4.2), whereas those with stroke occurring Ͼ3 years before baseline had RR of dementia of 1.1 (95% CI, 0.6 to 2.3). Among those with APOE information, individuals with only history of stroke (that occurred within 3 years before baseline) had RR of 3.1 (95% CI, 1.4 to 6.6), individuals with only the APOE ⑀4 allele had RR of 1.7 (95% CI, 1.1 to 2.5), and individuals with both factors had RR of 5.3 (95% CI, 2.1 to 13.4). The corresponding figures when incident stroke was examined instead of history of stroke were 2.3 (95% CI, 1.3 to 4.1), 1.7 (95% CI, 1.1 to 2.4), and 4.6 (95% CI, 2.0 to 10.6), respectively. The RR of interaction term for history of stroke and APOE ⑀4 was 1.1 (95% CI, 0.3 to 3.8; Pϭ0.8). The corresponding figure was 1.2 (95% CI, 0.4 to 4.4; Pϭ0.7) for incident stroke and APOE ⑀4. Furthermore, the RRs of dementia without any stroke and dementia with stroke in relation to APOE ⑀4 were 1.6 (95% CI, 1.1 to 2.3) and 1.2 (95% CI, 0.6 to 2.4), respectively. In addition, the APOE ⑀4 allele was not significantly related to the occurrence of stroke (RRϭ0.8; 95% CI, 0.5 to 1.5). Conclusions-A relatively fresh stroke is a risk factor for dementia. APOE ⑀4 increases the risk of dementia without stroke but not dementia with stroke. Our data do not support a multiplicative effect of stroke and the APOE ⑀4 allele on the risk of dementia. However, both factors seem to have an additive effect on the risk of dementia. The APOE ⑀4 allele does not increase the risk of stroke in this Swedish elderly population. (Stroke. 2000;31:53-60.)

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Use of Cardiovascular Drugs in an Older Swedish Population

Abstract: CV drugs are used commonly in older people. We suggest that the symptoms correlating with cardiac glycoside use may be signs of unrecognized toxicity, and this may relate to our finding that drug use is often not tailored to renal function as measured by creatinine clearance.

Cited by 21 publications

References 19 publications

Chronic constipation in hemiplegic patients

Chronic constipation in hemiplegic patients

Use of cardiovascular drugs by home-dwelling coronary patients aged 75 years and older

Incidence of Dementia in Relation to Stroke and the Apolipoprotein E ε4 Allele in the Very Old

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