Use of Cardiac Markers for Monitoring of Doxorubixin-induced Cardiotoxicity in Children With Cancer

Pongprot, Yupada; Sittiwangkul, Rekwan; Charoenkwan, Pimlak; Silvilairat, Suchaya

doi:10.1097/mph.0b013e31826faf44

Cited by 40 publications

(35 citation statements)

References 32 publications

(24 reference statements)

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“…Indices were calculated on data averaged from a minimum of three consecutive cardiac cycles wherever possible. The myocardial performance index 69 or the Tei index of the LV was calculated using Doppler flow intervals as follows: Tei index ¼ isovolumic contraction time þ isovolumic relaxation time)/LV ejection time. All measurements were calculated with the VEVO Analysis software (version 2.2.3).…”

Section: Methodsmentioning

confidence: 99%

Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function

Traister

Aafaqi

et al. 2014

Nat Commun

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Human dilated cardiomyopathy (DCM) manifests as a profound reduction in biventricular cardiac function that typically progresses to death or cardiac transplantation. There is no effective mechanism-based therapy currently available for DCM, in part because the transduction of mechanical load into dynamic changes in cardiac contractility (termed mechanotransduction) remains an incompletely understood process during both normal cardiac function and in disease states. Here we show that the mechanoreceptor protein integrin-linked kinase (ILK) mediates cardiomyocyte force transduction through regulation of the key calcium regulatory protein sarcoplasmic/endoplasmic reticulum Ca 2 þ ATPase isoform 2a (SERCA-2a) and phosphorylation of phospholamban (PLN) in the human heart. A non-oncogenic ILK mutation with a synthetic point mutation in the pleckstrin homology-like domain (ILK R211A ) is shown to enhance global cardiac function through SERCA-2a/PLN. Thus, ILK serves to link mechanoreception to the dynamic modulation of cardiac contractility through a previously undiscovered interaction with the functional SERCA-2a/PLN module that can be exploited to rescue impaired mechanotransduction in DCM.

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Section: Methodsmentioning

confidence: 99%

Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function

Traister

Aafaqi

et al. 2014

Nat Commun

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“…Some authors studied the association and relationship between natriuretic peptides and diastolic LV dysfunction, and others simply checked systolic LV function. However, only a few studies 55,[63][64][65][66][67] evaluated the potential predictive value of natriuretic peptide concentrations to detect the ongoing development of cardiac dysfunction.…”

Section: Natriuretic Peptides As Markers Of Ct-induced Cardiotoxicitymentioning

confidence: 99%

Biomarkers for the early detection of anthracycline-induced cardiotoxicity: current status

Horáček¹,

Vašatová²,

Pudil³

et al. 2014

BIOMED PAP

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Background. Cardiotoxicity is a well-known and potentially serious complication of anticancer therapy. Anthracyclinebased chemotherapy represents the greatest risk. Early detection of cardiotoxicity is crucial for applying preventive and supportive therapeutic strategies. Methods and Results. Various methods have been recommended for monitoring of cardiotoxicity. In our conditions, echocardiography and electrocardiography are routinely used. However, this approach shows low sensitivity for the early prediction of cardiomyopathy when the possibilities of appropriate management could still improve the patient's outcome. Recently, biomarkers of cardiac injury have been investigated in the assessment of chemotherapy-induced cardiotoxicity. Cardiospecific biomarkers, such as cardiac troponins, show high diagnostic efficacy in the early subclinical phase of the disease before the clinical onset of cardiomyopathy. Increase in their concentrations correlates with disease severity. As for natriuretic peptides, some studies, including ours, have shown promising results. Definitive evidence of their diagnostic and prognostic role in this context is still lacking and natriuretic peptides have not been routinely used for monitoring of cardiotoxicity in clinical practice. Other perspective biomarkers of cardiotoxicity in oncology are under study, especially heart-type fatty acid-binding protein (H-FABP) and glycogen phosphorylase BB (GPBB). Our studies using GPBB have provided encouraging results. However, the available data are limited and their practical use in this context cannot be recommended until their clinical efficacy is clearly defined. Conclusions. This review covers the current status of biomarkers for the early detection of anthracycline-induced cardiotoxicity. The authors present in brief, their own experience with multiple biomarkers in the detection of cardiotoxicity.

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“…In the clinic, anthracycline-induced cardiotoxicity (AIC) is characterized as ventricular dysfunction with no symptoms in ≤57% of patients, and clinical heart failure after cardiomyopathy in ≤16% of the patients (3,6,7). In general, the risk of developing AIC is closely linked to the cumulative dose of anthracyclines (8,9). Furthermore, other factors such as age and gender may also contribute to the occurrence of AIC (1).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, serum BNP levels are increased in patients with symptomatic LV dysfunction, indicating that BNP may be linked to the prognosis of heart failure (19). In recent years, serum BNP level was demonstrated to have relevance to the pathogenesis of AIC (9,11). BNP is secreted by ventricular cardiac cells and released into the blood in response to myocardial stretch, ventricular dilatation and increased pressure load of LV chambers, which are influenced by LV diastolic dysfunction (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

“…Once patients exhibit symptoms of cardiac failure, reversal of the condition via termination of anthracycline therapy may become impossible (10). Thus, it is important to detect AIC as early as possible (9). Multiple studies have demonstrated that B-type natriuretic peptide (BNP), a neurohormone secreted in the cardiac ventricles, reflect left ventricular (LV) end diastolic pressure and pulmonary capillary wedge pressure, and may independently predict AIC (1,11).…”

Section: Introductionmentioning

confidence: 99%

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Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity

2016

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Abstract.Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high quality studies published in peer-reviewed journals. Relevant studies were identified through literature searches of China National Knowledge Infrastructure (CNKI), Web of Science, PubMed, Google Scolar and China BioMedicine (CBM). STATA software was used in this meta-analysis for statistical analysis. In addition, the crude standardized mean difference (SMD) with 95% confidence interval (CI) for the highest vs. the lowest category of serum BNP levels was calculated. A total of 8 independent case-control studies, containing 126 AIC patients and 569 healthy controls, were included for the current meta-analysis. The results indicated a significant difference in serum BNP levels between the cardiotoxic group and normal group, with respect to post-treatment and pretreatment with anthracyclines. Specifically, the serum levels of BNP increased remarkably after treatment with anthracyclines in the cardiotoxic group, compared with the normal group. No publication bias was detected in this meta-analysis. The findings of the present study provide strong evidence that serum BNP levels may be associated with AIC.

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Use of Cardiac Markers for Monitoring of Doxorubixin-induced Cardiotoxicity in Children With Cancer

Cited by 40 publications

References 32 publications

Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function

Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function

Biomarkers for the early detection of anthracycline-induced cardiotoxicity: current status

Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity

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