Use of Capecitabine After Renal Allograft Transplantation in Dog Erythrocyte Antigen‐Matched Dogs

Abstract

CAP-CsA-prednisolone is an effective, oral immunosuppressive regimen for prevention of acute allograft rejection in DEA-matched beagles. Further studies on dose, toxicity, and efficacy compared with current immunosuppressive regimens are needed before use in clinical practice.

Use of Capecitabine to Prevent Acute Renal Allograft Rejection in Dog Erythrocyte Antigen‐Mismatched Mongrel Dogs

“…Given that these dogs seemed to have an increased frequency of transient acute gastrointestinal signs but nonetheless gained weight throughout the study, the significance of this lesion is unknown. None of the dogs had evidence of Helicobacter pylori infection as was noted in our previous study using a similar treatment protocol 26 …”

“…Concurrent treatment with ketoconazole reduces CsA dose requirements 31 . However, in a previous study, 26 it was suggested that ketoconazole may have potentiated neurotoxic effects of CAP. That surmise remains equivocal because 2 dogs in that study had toxic side effects, albeit less severe, without being administered ketoconazole.…”

“…When used as sole immunosuppressive agents in canine renal allograft recipients, most antimetabolites studied have elicited unacceptably high adverse reactions such as anorexia, weight loss, gastrointestinal ulceration, and anemia 11,17,22 . Thus, the combination of antimetabolites with calcineurin inhibitors such as CsA or tacrolimus has been used to reduce the necessary antimetabolite doses, leading to decreased toxicity and increased efficacy in preventing rejection 11–14,17,22,24,26 …”

“…Use of an immunomodulatory regimen consisting of CAP, CsA, and prednisolone in dog erythrocyte antigen (DEA)‐matched beagle dogs that had renal allografts yielded encouraging results 26 . Six of 8 dogs survived the 90 day study period while maintaining normal serum creatinine (Cr) concentrations and having minimal histologic evidence of graft rejection at necropsy.…”

Validation of a model of feline ureteral obstruction as a tool for teaching microsurgery to veterinary surgeons

“…Experienced surgeons were recruited for their expertise relating to microsurgery . Specifically, criteria for inclusion of expert microsurgeons were >10 years experience with ureteral surgery, performance of at least 10‐15 feline ureteral surgeries or comparable laboratory animal microsurgeries per year, and significant experience with feline renal transplantation.…”