Use of Canagliflozin in Combination With and Compared to Incretin-Based Therapies in Type 2 Diabetes

Abstract

In Brief Sodium–glucose cotransporter 2 (SGLT2) inhibitors and incretin-based therapies (dipeptidyl peptidase-4 [DPP-4] inhibitors and glucagon-like peptide-1 [GLP-1] receptor agonists) are widely used to treat patients with type 2 diabetes. In clinical and real-world studies, canagliflozin, an SGLT2 inhibitor, has demonstrated superior A1C lowering compared to the DPP-4 inhibitor sitagliptin. Canagliflozin can also promote modest weight/fat loss and blood pressure reduction. The addition of canagliflozin to treatment regimens that include a DPP-4 inhibitor or a GLP-1 receptor agonist has been shown to further improve glycemic control, while still maintaining beneficial effects on cardiometabolic parameters such as body weight and blood pressure. Overall, the available clinical and real-world evidence suggests that canagliflozin is a safe and well-tolerated treatment option that can be considered either in addition to or instead of incretin-based therapies for patients with type 2 diabetes.

Potential Inhibitors of Lumpy Skin Disease’s Viral Protein (DNA Polymerase): A Combination of Bioinformatics Approaches

“…Canagliflozin and tepotinib are repurposed drugs, which means they have already been approved for use in treating specific diseases, and currently, there is interest in exploring their potential use for different diseases, including LSD. Canagliflozin (Invokana) is primarily used for the treatment of type 2 diabetes [90][91][92]. Canagliflozin exhibits a high capacity to bind plasma proteins (99%), mainly albumin.…”