Use of calcium hydroxylapatite (Radiesse&lt;sup&gt;&amp;reg;&lt;/sup&gt;) for facial augmentation

Jacovella, Patricio F.

doi:10.2147/cia.s2065

Cited by 99 publications

(92 citation statements)

References 35 publications

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“…An adult pig model of post-MI remodeling was used whereby injections of CHAM (carboxymethylcellulose, Radiesse; Bioform Medical Inc., San Mateo, CA) were performed at the time of MI induction (Dixon et al, 2011;Morita et al, 2011). CHAM has been used clinically as a dermal filler for facial augmentation whereby the CHAM microspheres (25-45 mm diameter) are suspended in a gel carrier composed of glycerin (Ahn, 2007;Jacovella, 2008). The disposition of CHAM following injections is that of a bioceramic, whereby the gel carrier degrades quickly and is then followed by a more prolonged cell-dependent biodegradable process of the microspheres (Ahn, 2007;Jacovella, 2008;Dixon et al, 2011;Tous et al, 2012;Shuman et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

“…CHAM has been used clinically as a dermal filler for facial augmentation whereby the CHAM microspheres (25-45 mm diameter) are suspended in a gel carrier composed of glycerin (Ahn, 2007;Jacovella, 2008). The disposition of CHAM following injections is that of a bioceramic, whereby the gel carrier degrades quickly and is then followed by a more prolonged cell-dependent biodegradable process of the microspheres (Ahn, 2007;Jacovella, 2008;Dixon et al, 2011;Tous et al, 2012;Shuman et al, 2013). More specifically, CHAM is cleared by a macrophage-dependent process, which is then accompanied by proliferation of fibroblasts (Shumaker et al, 2006;Ahn, 2007;Jacovella, 2008;Dixon et al, 2011;Tous et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

“…The disposition of CHAM following injections is that of a bioceramic, whereby the gel carrier degrades quickly and is then followed by a more prolonged cell-dependent biodegradable process of the microspheres (Ahn, 2007;Jacovella, 2008;Dixon et al, 2011;Tous et al, 2012;Shuman et al, 2013). More specifically, CHAM is cleared by a macrophage-dependent process, which is then accompanied by proliferation of fibroblasts (Shumaker et al, 2006;Ahn, 2007;Jacovella, 2008;Dixon et al, 2011;Tous et al, 2012). These cell types, the macrophage and fibroblast, play a critical role in the post-MI remodeling process (Lindsey et al, 2001;Ertl and Frantz, 2005;Hohensinner et al, 2010;Frangogiannis, 2012;Freytes et al, 2013;Goldsmith et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

“…The selection of CHAM for the present study was predicated upon past evidence in large animal models that injections of this microsphere formulation were effective in attenuating the post-MI remodeling process (Dixon et al, 2011;Morita et al, 2011), and that this specific formulation has significant clinical exposure, thus holding potential translational relevance (Ahn, 2007;Jacovella, 2008). Since this is a standardized formulation, then whether and to what degree a higher concentration of microspheres or other degradable carriers would affect post-MI remodeling, and more specifically the biologic response variables measured in the present study, remains unknown.…”

Section: Downloaded Frommentioning

confidence: 99%

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Targeted Injection of a Biocomposite Material Alters Macrophage and Fibroblast Phenotype and Function following Myocardial Infarction: Relation to Left Ventricular Remodeling

McGarvey

Pettaway

Shuman

et al. 2014

J Pharmacol Exp Ther

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A treatment target for progressive left ventricular (LV) remodeling prevention following myocardial infarction (MI) is to affect structural changes directly within the MI region. One approach is through targeted injection of biocomposite materials, such as calcium hydroxyapatite microspheres (CHAM), into the MI region. In this study, the effects of CHAM injections upon key cell types responsible for the MI remodeling process, the macrophage and fibroblast, were examined. MI was induced in adult pigs before randomization to CHAM injections (20 targeted 0.1-ml injections within MI region) or saline. At 7 or 21 days post-MI (n 5 6/time point per group), cardiac magnetic resonance imaging was performed, followed by macrophage and fibroblast isolation. Isolated macrophage profiles for monocyte chemotactic macrophage inflammatory protein-1 as measured by real-time polymerase chain reaction increased at 7 days post-MI in the CHAM group compared with MI only (16.3 6 6.6 versus 1.7 6 0.6 cycle times values, P , 0.05), and were similar by 21 days post-MI. Temporal changes in fibroblast function and smooth muscle actin (SMA) expression relative to referent control (n 5 5) occurred with MI. CHAM induced increases in fibroblast proliferation, migration, and SMA expression-indicative of fibroblast transformation. By 21 days, CHAM reduced LV dilation (diastolic volume: 75 6 2 versus 97 6 4 ml) and increased function (ejection fraction: 48 6 2% versus 38 6 2%) compared with MI only (both P , 0.05). This study identified that effects on macrophage and fibroblast differentiation occurred with injection of biocomposite material within the MI, which translated into reduced adverse LV remodeling. These unique findings demonstrate that biomaterial injections impart biologic effects upon the MI remodeling process over any biophysical effects.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Downloaded Frommentioning

confidence: 99%

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Targeted Injection of a Biocomposite Material Alters Macrophage and Fibroblast Phenotype and Function following Myocardial Infarction: Relation to Left Ventricular Remodeling

McGarvey

Pettaway

Shuman

et al. 2014

J Pharmacol Exp Ther

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“…[56] After the gel degrades in 2-3 months, the microspheres promote the formation of new tissue formation by collagen deposition. [57] Results typically last for 12-18 months [58][59][60] leaving behind calcium and phosphate ions after undergoing the phagocytosis process by the macrophages. [57] A study conducted by Marmur et al [57] evaluated the histologic and electron microscopic structural changes observed following CaHA injection at 1 and 6 months.…”

Section: Poly-l-lactic Acidmentioning

confidence: 99%

Intradermal fillers for minimally invasive treatment of facial aging

Lin¹,

Shah²,

Dhinakar³

et al. 2016

PAR

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The ever-increasing interest in retaining a youthful physical appearance has facilitated the development of various minimally invasive dermatological techniques. The use of intradermal fillers can be incorporated into dermatological practices with minimal overhead costs. This strategy addresses facial volume loss and dynamic lines, which are the main features of facial aging. Moreover, intradermal fillers provide an array of flexible treatment options for a balanced and holistic result to dermatological practitioners. This paper reviews the different intradermal fillers categorized by biodegradable and non-permanent fillers including collagen based materials, hyaluronic acid and autologous fat, semi-permanent fillers including poly methyl methacrylate, poly-L-lactic acid and calcium hydroxyapatite microspheres, and permanent fillers including silicone. A discussion is provided of the commercial products made of these materials and their clinical efficacy in the treatment of facial aging. Key words:Intradermal fillers; facial aging; volumization; biodegradable and non-permanent fillers; semipermanent fillers; permanent fillers Xin Zhao is an associate professor at Xi'an Jiaotong University, China. Prior to starting this appointment, she was a postdoctoral fellow at Medical School and School of Engineering and Applied Sciences at Harvard University. Her research involves engineering the micro-and nanoscale systems for tissue regeneration and drug delivery.

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Calcium Hydroxylapatite Nodule Resolution After Fractional Carbon Dioxide Laser Therapy

Reddy

Brauer²,

Anolik³

et al. 2012

Arch Dermatol

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Background: Injection of calcium hydroxylapatite filler may result in nodule formation owing to superficial placement of the filler. Calcium hydroxylapatite nodules are difficult to reverse. Previously reported therapeutic options are limited and include intralesional triamcinolone, massage, needling, and excision, each with inconsistent results or potential for scarring. Observation: We have observed complete resolution of calcium hydroxylapatite nodules after a single treatment with fractional carbon dioxide laser. Conclusions: A single session of fractional carbon dioxide laser treatment may resolve selected cases of calcium hydroxylapatite nodules. The mechanism of action may involve conversion of the product into tricalcium phosphates which dissolve readily. This novel therapeutic technique may enhance treatment options for a difficult clinical problem.

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Use of calcium hydroxylapatite (Radiesse<sup>®</sup>) for facial augmentation

Cited by 99 publications

References 35 publications

Targeted Injection of a Biocomposite Material Alters Macrophage and Fibroblast Phenotype and Function following Myocardial Infarction: Relation to Left Ventricular Remodeling

Targeted Injection of a Biocomposite Material Alters Macrophage and Fibroblast Phenotype and Function following Myocardial Infarction: Relation to Left Ventricular Remodeling

Intradermal fillers for minimally invasive treatment of facial aging

Calcium Hydroxylapatite Nodule Resolution After Fractional Carbon Dioxide Laser Therapy

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