Use of Bupropion and Topiramate in Management of Tianeptine Abuse in a Young Male with Dysthymia

Tianeptine

“…Fortunately, there is preliminary evidence through case reports to support off-label use of buprenorphine in the treatment of tianeptine withdrawal when used as a taper (Nabil et al, 2018). Other case reports suggest that buprenorphine can be used for maintenance to mitigate risk of tianeptine use recurrence (Trowbridge & Walley, 2019), and another case report has suggested bupropion and topiramate to mitigate tianeptine misuse (Chawla & Kar, 2022).…”