“…Large doses of this agent ( i.e. , 30 mg. daily) have been administered buccally to diabetics over a period of months without significant toxicity and with apparent amelioration of an associated nephrotic syndrome (110). Studies involving the supportive use of similar agents, including parenteral administration of chymotrypsin (Chymar, Aqueous) 2 and oral administration of chymotrypsin plus trypsin (Chymoral) 2 are in progress.…”