Use of bromazepam in obsessional, phobic and related states

Burrell, R. H.; Culpan, Roger; Newton, K. J.; Ogg, G. J.; Short, Jackie

doi:10.1185/03007997409112660

Cited by 11 publications

(1 citation statement)

References 4 publications

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“…Like all benzodiazepines, bromazepam proved to possess muscle relaxing activity, antineurotic and sedative effects [3][4][5]. The most characteristic effect of bromaze-DOI: 10.1159/000499371 pam is its anxiolytic power [6], which in clinical trials has been shown to be at least equal to [7,8] or superior than [9][10][11] that of diazepam and of lorazepam [12].…”

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confidence: 99%

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

et al. 2019

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Aim: To assess the effects of chronic evening oral administration of bromazepam alone or in combination with propranolol on ambulatory blood pressure (BP) and heart rate (HR) in mild hypertensive subjects. Methods: Thirty-seven mild hypertensive patients after a 2-week placebo period were randomized to bromazepam 3 mg, propranolol 40 mg, bromazepam 3 mg plus propranolol 40 mg or placebo for 2 weeks according to a double-blind, double dummy, cross-over design. After each treatment period, 24-h BP and HR ambulatory monitoring was performed by using a non-invasive device. Results: Ambulatory monitoring showed that during night-time SBP and DBP values were unaffected by bromazepam as compared to placebo, whereas SBP was significantly reduced by propranolol both when taken alone and in combination with bromazepam. HR nocturnal values were significantly reduced by propranolol, whereas they were significantly increased by bromazepan both when taken alone (+11.5%, p < 0.05 vs. placebo) and in combination with propranolol (+12.8%, p < 0.05 vs. propranolol). No significant difference in day-time values of SBP, DBP and HR was observed among the 4 treatment groups. Conclusions: In mild hypertensive patients, evening consumption of bromazepam for a 2-week period did not affect BP, while it increased nocturnal HR. Such an increase was observed both when bromazepam was taken alone and in combination with propranolol, which suggests that it depends on a bromazepam mediated decrease in vagal tone. Whatever the mechanism, the HR nocturnal increase might be of clinical relevance, due to the role of high HR as cardiovascular risk factor, particularly in already at risk hypertensive subjects.

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Section: Introductionmentioning

confidence: 99%

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

et al. 2019

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Pharmacotherapy of Obsessive‐Compulsive Disorder

Jermain,

Crismon

1990

Pharmacotherapy

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Obsessive‐compulsive disorder (OCD) is a potentially devastating illness, both to the patient and family members. Its etiology is unclear, but some evidence points toward dysfunction in an orbitofrontal striatal‐limbic neuronal loop. Although many agents have been used, clomipramine, a tricyclic antidepressant, appears to be the most promising therapy. Clomipramine was approved by the Food and Drug Administration and released for general use in early 1990 under the brand name Anafranil. Clomipramine's adverse effect profile is similar to that of currently marketed tricyclic antidepressants; however, it is associated with a higher frequency of seizures, estimated to be 0.7%. Although other serotonergic agents such as fluoxetine have shown promise in OCD, they have been studied only in a limited number of patients. Other agents, with the possible exception of monoamine oxidase inhibitors, either have resulted in inconsistent improvement or have been reported in an anecdotal fashion.

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Pharmacotherapy of Obsessive-Compulsive Disorder

Ananth

1985

Obsessive-Compulsive Disorder

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Use of bromazepam in obsessional, phobic and related states

Cited by 11 publications

References 4 publications

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

Pharmacotherapy of Obsessive‐Compulsive Disorder

Pharmacotherapy of Obsessive-Compulsive Disorder

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