Use of Botox (OnabotulinumtoxinA) for the Treatment of Parotid Sialocele and Fistula After Extirpation of Buccal Squamous Cell Carcinoma With Immediate Reconstruction Using Microvascular Free Flap: A Report of 3 Cases

Melville, James C.; Stackowicz, Daniel; Jundt, Jonathon S.; Shum, Jonathan

doi:10.1016/j.joms.2016.01.038

Cited by 22 publications

(12 citation statements)

References 27 publications

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“…The total number of subjects across all studies was 47 patients. The largest study had 16 participants while the smallest included manuscript had 1 subject . The mean sample size of all included studies was 3.5 (SD 40.8).…”

Section: Resultsmentioning

confidence: 99%

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Botulinum toxin A is an effective therapeutic tool for the management of parotid sialocele and fistula: A systematic review

Maharaj

Mungul

Laher

2020

Laryngoscope Investig Oto

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Objectives In the management of parotid sialocele and fistula, various conservative and surgical methods have been described. Some studies have described the use of Botulinum toxin A (Botox A) for the management of parotid sialocele and fistula. This is a less invasive and potentially equally effective option. We therefore conducted a systematic review on the current body of literature relating to this specific use of Botox A. Methods A search strategy was conducted in July 2019 using the following electronic databases: Cochrane Database of Systematic Reviews, EMBASE, Google Scholar, PubMed, Scopus, and Web of Science. A search of all articles from inception until 31 August 2019 was performed. Results Literature searches of electronic databases identified 67 articles eligible for review, of which 15 fulfilled all criteria. These studies were small and in total only 47 patients were included. The majority of sialoceles and fistulas presented as a complication of surgery (77%) with the remaining cases occurring as a result of trauma. The typical age at presentation was between 32 and 88 years of age (mean age of 52 years). All patients were initially treated with and failed other conservative measures. Botox A injection was considered as a final conservative treatment option. The toxin was administered percutaneously in all cases of parotid sialocele and fistula. Dosage of Botox ranged from 10 to 200 units with majority of patients (58%) requiring only one injection. The overall success rate for patients treated with Botox A injections ranged between 70 and 100% for parotid sialoceles and fistulas. Conclusion Botox A injections are successful in the treatment of parotid sialoceles and fistulas and should be considered before the use of invasive conventional options. Further studies with larger numbers are needed to ratify this recommendation. Success rate for patients, treated with Botox A injection was between 70 and 100% for parotid sialocele and fistula. Patients who failed initial treatment with Botox A were re‐administered with Botox A and eventually resolved.

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Section: Resultsmentioning

confidence: 99%

“…Among the 15 studies, three were conducted in the United States and Germany, respectively, and one in Turkey, United Kingdom, Hong Kong, India, Brazil, Italy, South Korea, France, and New Zealand, respectively.…”

Section: Resultsmentioning

confidence: 99%

Botulinum toxin A is an effective therapeutic tool for the management of parotid sialocele and fistula: A systematic review

Maharaj

Mungul

Laher

2020

Laryngoscope Investig Oto

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“…BTA injections into glandular tissue can be performed either under ultrasound guidance, or by palpation by experienced physicians [14]. Injection techniques are less invasive, costly and require less technical skill to perform compared to alternative surgical interventions.…”

Section: Discussionmentioning

confidence: 99%

Type a botulinum toxin in the management of spontaneous salivary otorrhea: A case report

Chan

Lewis

Sommer

2020

Journal of Otolaryngology - Head & Neck Surgery

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Background: Spontaneous salivary otorrhea is a rare presentation only previously documented twice in literature where parotid salivary secretions are found in the external auditory canal. Conventional treatment of spontaneous parotid salivary fistulas includes surgical management with interposed grafts, fistula tract ablation, and possible superficial parotidectomy. Associated risks include facial nerve injury, Frey syndrome and facial scarring. Here we report the first case of spontaneous salivary otorrhea conservatively managed with a type A botulinum toxin (BTA) injection. Case presentation: A 17-year-old female presented with a 5-month history of left sided otorrhea and transient left facial swelling associated with gustatory stimulation. The otorrhea fluid tested positive for salivary amylase and negative for beta 2 transferrin. Fifty units of BTA were injected into the left parotid gland under ultrasound guidance. Cessation of symptoms was achieved 3 weeks after intervention. The patient remains symptom-free at the 2 year follow up. Conclusion: BTA injection was well tolerated under ultrasound guidance and has led to long-term resolution of the patient's symptoms. BTA injection appears to be a safe and effective way to conservatively manage this rare presentation of spontaneous salivary otorrhea.

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“…Dessy et al [ 10 ] reported the effectiveness of botulinum toxin injection for a parotid fistula after face-lift surgery. There have been described numerous methods for administering botulinum toxin injection to treat a fistula, but no consensus currently exists regarding the amount, approach or site to prevent paralysis of the facial nerve [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Botulinum Toxin on an Iatrogenic Sialo-Cutaneous Fistula

Hong

Kwon

Kang

et al. 2016

Arch Craniofac Surg

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A sialo-cutaneous fistula is a communication between the skin and a salivary gland or duct discharging saliva. Trauma and iatrogenic complications are the most common causes of this condition. Treatments include aspiration, compression, and the administration of systemic anticholinergics; however, their effects are transient and unsatisfactory in most cases. We had a case of a patient who developed an iatrogenic sialo-cutaneous fistula after wide excision of squamous cell carcinoma in the parotid region that was not treated with conventional management, but instead completely resolved with the injection of botulinum toxin. Based on our experience, we recommend the injection of botulinum toxin into the salivary glands, especially the parotid gland, as a conservative treatment option for sialo-cutaneous fistula.

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Use of Botox (OnabotulinumtoxinA) for the Treatment of Parotid Sialocele and Fistula After Extirpation of Buccal Squamous Cell Carcinoma With Immediate Reconstruction Using Microvascular Free Flap: A Report of 3 Cases

Cited by 22 publications

References 27 publications

Botulinum toxin A is an effective therapeutic tool for the management of parotid sialocele and fistula: A systematic review

Botulinum toxin A is an effective therapeutic tool for the management of parotid sialocele and fistula: A systematic review

Type a botulinum toxin in the management of spontaneous salivary otorrhea: A case report

The Effect of Botulinum Toxin on an Iatrogenic Sialo-Cutaneous Fistula

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