Use of Black Seed (Nigella Sativa L.) Oil in the Management of Hypertensive and Hyperlipidemic Individuals of District Muzaffarabad, Azad Kashmir, Pakistan

Abstract

Abstract. Hypertension and hyperlipidemia are two main causes of cardiovascular diseases with rapidly increasing pervasiveness worldwide. Complimentary alternative medicines provide an effective choice to these highly prevalent global health issues. Nigella sativa has diverse range of traditional and pharmacological potential with established safety profile. This study was carried out in 163 mildmoderate hypertensive and hyperlipidemic patients. Patients were selected randomly of both genders. The patient's age ranges between 20-65 years. This clinical study was conducted to evaluate the clinical effect of Nigella sativa virgin oil in hypertension and hyperlipidemic patients of the selected region and also assess its antioxidative potential. The results conferred that N. sativa has significant (< 0.05) effect on controlling hypertension and hyperlipidemia as compared to standards used. Moreover, N. sativa conferred excellent antioxidant potential as compared to other commercially available edible oils.

The Use of Nigella sativa in Cardiometabolic Diseases

“…Hussain et al demonstrated that the consumption of virgin Nigella sativa oil at the dose of 1 mL/day in 146 mild-moderate hypertensive and hyperlipidemic patients for 45 days significantly reduced systolic (SBP) and diastolic blood pressure (DBP) (p < 0.05) as compared to the baseline. Regarding the lipid profile, the supplement produced a significant decrease in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (Tg) and an increase in high-density lipoprotein cholesterol (HDL-C) (p < 0.05 for all) compared to initial values [26].…”

Designing novel industrial and functional foods using the bioactive compounds from Nigella sativa L. (black cumin): Biochemical and biological prospects toward health implications

“…Qidwai et al (2009) black nigella seeds contain bioactive components like thymol that could reduce blood pressure by blocking calcium channels (Ramadan, 2007). Black cumin oil (0.5 mL/twice a day/45 days) decreased systolic blood pressure and diastolic blood pressure in subjects with mild to moderate hypertension (Hussain et al, 2017). Doses of the volatile oil of N. sativa (4-32 µL/kg) administered intravenously to urethane-treated rats significantly reduced the heart rate and systemic arterial pressure (El Tahir et al, 1993).…”

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

“…However, in a randomized controlled clinical trial in elderly patients with hypertension, black cumin administration (300 mg black cumin seed extract twice daily for 28 days) showed a slight but insignificant reduction in blood pressure [ 146 ]. On the contrary, a clinical study on patients with mild–moderate hypertension using black cumin virgin oil demonstrated positive outcomes on lipid profiles and blood pressure [ 147 ]. With the evidence stated here and in the previous sections, it can be anticipated that black cumin can be a promising candidate for developing therapeutics against heart diseases, provided that the controversies raised in some studies are properly resolved by employing appropriate experimental models.…”