Abstract:Bioequivalence testing is the initial approach for the analysis of quantitative determination of drugs and their metabolism in biological samples. In this research work its applications was tested and reviewed under different sampling techniques. The basic concept of bioequivalence testing crossover design was used to make assessment of medicine for breast cancer methotrexate and tamoxifen. Effectiveness of methotrexate at initial stage was 2.38 and at advance stage it was 1.85 which means it was 43% e… Show more
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