Use of azoximer bromide for treatment of children's inflammatory infections of respiratory system: a meta-analysis of controlled clinical studies

Abstract

Use of azoximer bromide for treatment of children's inflammatory infections of respiratory system: a meta-analysis of controlled clinical studies.

Efficacy and safety of azoximer bromide (Polyoxidonium) in children aged from 1 to 12 years with ARI: The results of a multicenter prospective, randomized, double-blind, placebo-controlled, parallel-group study

“…Vavilova et al studies [3]. Meta-analysis of the clinical studies data also confirmed that the terms of normalization of body temperature at inclusion of azoximer bromide (Polyoxidonium) in therapy of children with infectious and inflammatory diseases are reduced by 1.4 (according to the model of fixed effects) -1.92 days (according to the model of random effects) [2]. The fever was expected to last for a longer period than they eventually got when planning this study, taking into account the presented results of previous studies.…”

“…The main mechanism of the immunomodulatory action of bromide azoximer is direct action on phagocytic cells and natural killers, as well as stimulation of antibody formation and interferon-alpha and interferon-gamma synthesis. The studies show that azoximer bromide increases the phagocytic activity of macrophages and neutrophils [2,3]. In vitro study has shown that this drug is able to inhibit the formation of suicidal neutrophil extracellular traps (NET) [4].…”

“…In vitro study has shown that this drug is able to inhibit the formation of suicidal neutrophil extracellular traps (NET) [4]. Several studies have shown that the severity of rhinoviral infection and influenza, acute moderate otitis, acute and chronic rhinosinusitis, pneumonia and other infectious diseases is correlated with the level of NET formation [2,5,6].…”

“…The anti-inflammatory action of azoximer bromide is realized by normalization of pro-and anti-inflammatory cytokines synthesis and also connected with suppression of NET formation. Detoxifying properties are explained by the peculiarity of the molecule structure -a large number of different active groups on its surface, which intensively bind soluble toxic substances and micro-particles circulating in blood [2].…”

Pathogenetically-oriented therapy for novel coronavirus infection

“…Показано, что одним из факторов, приводящих к усилению симптомов интоксикации и воспаления, а также ведущих к увеличению тяжести течения инфекционного заболевания, является образование нейтрофильных внеклеточных ловушек (НВЛ) [4,5]. При встрече с возбудителем заболевания нейтрофил выбрасывает во внеклеточное пространство сети, состоящие из ДНК, гистонов и содержимого секреторных гранул.…”