Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures

Gray, Patricia L.; Hoppes, Sharman; Suchodolski, Paulette F.; Mirhosseini, Negin; Payne, Susan; Villanueva, Itamar; Shivaprasad, H. L.; Honkavuori, Kirsi S.; Briese, Thomas; Reddy, Sanjay M.; Tizard, Ian R.

doi:10.3201/eid1603.091257

Cited by 94 publications

(125 citation statements)

References 27 publications

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“…The cause of PDD was unresolved until 2008, when Kistler et al (11) and Honkavuori et al (10) detected bornaviruses during investigations into the cause of the disease and identified several distinct avian bornavirus (ABV) genotypes. Subsequent identification of ABV sequences and/or antigen in brains of birds with neurologic illness supported the initial findings (21,22), and experimental challenge of parrots with brain homogenates (6) or ABV-infected duck embryo fibroblasts (DEF) (7,14) caused PDD-like lesions. Thus, avian bornaviruses are now recognized as potential pathogens with widespread distribution (18).…”

mentioning

confidence: 77%

Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis)

Payne

Covaleda

Guo

et al. 2011

J Virol

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mentioning

confidence: 77%

Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis)

Payne

Covaleda

Guo

et al. 2011

J Virol

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“…8 Briefly, for fecal samples, the swab was flushed with 0.2 mL phosphate buffered saline. No additions were made to the urine samples.…”

Section: Rna Purificationmentioning

confidence: 99%

“…A 5-µL aliquot of each cDNA sample was amplified by PCR using forward and reverse primers for each gene of interest. 8 For intestinal contents, fecal or urine PCR, ABV sequences were amplified using two multiplexed primer sets. One recognized M-protein genes; the other recognized conserved regions of the N genes.…”

Section: Rt-pcr Analysismentioning

confidence: 99%

Avian bornavirus in the urine of infected birds

Heatley

Villalobos²

2012

VMRR

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Avian bornavirus (ABV) causes proventricular dilatation disease in multiple avian species. In severe clinical disease, the virus, while primarily neurotropic, can be detected in many organs, including the kidneys. We postulated that ABV could be shed by the kidneys and found in the urine of infected birds. Immunohistochemical staining demonstrated viral N and P proteins of ABV within the renal tubules. We adapted a nonsurgical method of urine collection for use in parrots known to be shedding ABV in their droppings. We obtained urine without feces, and results were compared with swabs of fresh voided feces. Reverse transcription-polymerase chain reaction assay performed on these paired samples from five birds indicated that ABV was shed in quantity in the urine of infected birds, and a single sample was urine-positive and fecal-negative. We suggest that urine sampling may be a superior sample for detection of birds shedding ABV, and advocate that additional birds, known to be shedding or infected with ABV, should be investigated via this method.

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“…PDD is a fatal neurological disorder characterized by lymphoplasmacytic inflammation of the central and peripheral nervous system [38]. Because Koch's postulates were experimentally fulfilled, ABV has been considered the aetiological agent of PDD [39,40]. However, cases of asymptomatic infection have been reported occasionally, indicating that ABV infection does not always cause PDD and raising the importance of epidemiological studies of ABV [41][42][43].…”

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confidence: 99%

Comprehensive analysis of endogenous bornavirus-like elements in eukaryote genomes

Horie

Kobayashi

Suzuki

et al. 2013

Phil. Trans. R. Soc. B

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Bornaviruses are the only animal RNA viruses that establish a persistent infection in their host cell nucleus. Studies of bornaviruses have provided unique information about viral replication strategies and virus–host interactions. Although bornaviruses do not integrate into the host genome during their replication cycle, we and others have recently reported that there are DNA sequences derived from the mRNAs of ancient bornaviruses in the genomes of vertebrates, including humans, and these have been designated endogenous borna-like (EBL) elements. Therefore, bornaviruses have been interacting with their hosts as driving forces in the evolution of host genomes in a previously unexpected way. Studies of EBL elements have provided new models for virology, evolutionary biology and general cell biology. In this review, we summarize the data on EBL elements including what we have newly identified in eukaryotes genomes, and discuss the biological significance of EBL elements, with a focus on EBL nucleoprotein elements in mammalian genomes. Surprisingly, EBL elements were detected in the genomes of invertebrates, suggesting that the host range of bornaviruses may be much wider than previously thought. We also review our new data on non-retroviral integration of Borna disease virus.

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Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures

Abstract: The fulfillment of Koch’s postulates shows that the virus causes proventricular dilatation disease in parrots.

Cited by 94 publications

References 27 publications

Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis)

Detection and Characterization of a Distinct Bornavirus Lineage from Healthy Canada Geese (Branta canadensis)

Avian bornavirus in the urine of infected birds

Comprehensive analysis of endogenous bornavirus-like elements in eukaryote genomes

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