Use of Autologous Platelet Concentrate in Blepharoplasty Surgery

Vick, Valerie L.; Holds, John B.; Hartstein, Morris E.; Rich, Ryan; Davidson, Brent R.

doi:10.1097/01.iop.0000202092.73888.4c

Cited by 26 publications

(18 citation statements)

References 7 publications

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“…The use of APG to reduce ecchymosis and edema has received mixed reviews in clinical reports, and its clinical use remains controversial. [6][7][8] To investigate whether topical APG can accelerate acute skin healing in healthy individuals, we conducted a prospective study testing APG on full-thickness skin punch wounds in healthy subjects. Full-thickness dermal punch wounds were selected for the acute skin-healing model because the model is minimally invasive, technically straightforward to create, and easily followed up over time.…”

Section: Nnovative Devices For Process-mentioning

confidence: 99%

The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds

Hom

Linzie

Huang

2007

Archives of Facial Plastic Surgery

135

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Section: Nnovative Devices For Process-mentioning

confidence: 99%

The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds

Hom

Linzie

Huang

2007

Archives of Facial Plastic Surgery

135

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“…8 To date, only a few studies on the use of autologous platelet gel as an adhesive have been published in the field of plastic surgery. Existing data in various plastic surgery indications, including rhytidectomy, 9–11 abdominoplasty, 11–13 and breast reduction, 10,11 have shown encouraging results with a reduction in postoperative complications (ie, seroma and hematoma) after the use of autologous PRP (A-PRP) glue.…”

mentioning

confidence: 99%

Efficacy of Autologous Platelet-rich Plasma Glue in Weight Loss Sequelae Surgery and Breast Reduction: A Prospective Study

Hersant

SidAhmed-Mezi

Padula

et al. 2016

Plastic and Reconstructive Surgery - Global Open

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Background:Seroma and hematoma formations are the most common complications after plastic surgery. The aim of this study was to assess the efficacy of autologous platelet-rich plasma (A-PRP) glue to reduce postoperative wound complications and improve surgical outcomes.Methods:Fifty-four patients were included in this study. They underwent breast reduction surgery, abdominoplasty, or limb lifting with A-PRP glue application on the entire surface of the subcutaneous tissue at the time of suture. Retrospective data were used for the control group. The primary endpoint was the incidence of postoperative seroma or hematoma. The secondary endpoint was the Patient and Observer Scar Assessment Scale score.Results:Demographics and clinical characteristics were not statistically different between the A-PRP glue group and the control group regarding age, sex ratio, and body mass index. After abdominoplasty, 37.5% of patients (3/8) in the control group experienced seroma and hematoma complications versus 12.5% of patients (2/16) in the A-PRP glue group (P = 0.55 and P = 0.25, respectively). After limb lifting, 50% of patients experienced postoperative complications in the control group versus no patient in the A-PRP glue group (P = 0.03*; * indicates that the P value is significant). After breast reduction, no patient experienced complication in the A-PRP glue group versus 25% of patients in the control group who experienced hematoma (P = 0.04*). The scar quality assessed 12 months after surgery showed no statistical differences between the groups.Conclusions:A-PRP glue seems effective to prevent seroma formation after limb lifting and hematoma formation after breast reduction. Wound-healing quality did not seem to be improved.

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“…50 autologous platelet concentrate into eyelid incisions in an attempt to decrease edema and ecchymosis, but the improvement in postoperative edema and ecchymosis did not achieve clinical significance (Level II Evidence). 51 Major adverse postoperative events, such as retrobulbar hematoma, change or loss of vision, infection, iatrogenic ptosis, ectropion, or lagophthalmos, are rare. Transient malposition of the lids, chemosis, and symptomatic dryness requiring lubrication are occasionally seen in the immediate postoperative period, but the majority of these problems resolve with time.…”

Section: Evidence On Postoperative Outcomesmentioning

confidence: 99%

An Evidence-Based Approach to Blepharoplasty

Friedland

Lalonde

Rohrich

2010

Plastic and Reconstructive Surgery

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The Maintenance of Certification module series is designed to help the clinician structure his or her study in specific areas appropriate to his or her clinical practice. This article is prepared to accompany practice-based assessment of preoperative assessment, anesthesia, surgical treatment plan, perioperative management, and outcomes. In this format, the clinician is invited to compare his or her methods of patient assessment and treatment, outcomes, and complications, with authoritative, information-based references.This information base is then used for self-assessment and benchmarking in parts II and IV of the Maintenance of Certification process of the American Board of Plastic Surgery. This article is not intended to be an exhaustive treatise on the subject. Rather, it is designed to serve as a reference point for further in-depth study by review of the reference articles presented. (Plast. Reconstr. Surg. 126: 2222 CLINICAL SCENARIOA 56-year-old woman requests improvement in the appearance of her upper and lower eyelids. She had LASIK surgery 3 months earlier. She has ptosis of her left upper eyelid. What is the best evidence to guide you in the management of her condition? There is very little high level evidence in the blepharoplasty literature at this time. The age of evidence is just upon us, and objective measurement in aesthetic surgery is in its infancy. This article is a starting point where most of the evidence is level IV (case series) and level V (case reports or expert opinion). There is almost no level III evidence (retrospective comparative case series) and virtually no level II evidence (prospective comparative studies). It will be very difficult to create level I studies that are prospective randomized blinded controlled studies. Nevertheless, we have to start somewhere. One hundred years from now, there will be serious useful evidence-based studies in cosmetic plastic surgery, like looking from the top of a sky scraper. This is the first step at examining where we are in the basement of evidence based medicine in aesthetic blepharoplasty. METHODS FOR IDENTIFYING EVIDENCEA literature search of PubMed, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library was performed to obtain the best available evidence on blepharoplasty, with emphasis on preoperative assessment, treatment, and outcomes. The following search terms were combined as appropriate, and PubMed MeSH terms were used when available: blepharoplasty, eyelid surgery, diagnosis, preoperative assessment, risk factors, smoking, diabetes mellitus, pulmonary embolism, venous thrombosis, dry eye syndromes, anticoagulants, DVT prophylaxis, antibiotic prophylaxis, anesthetics, premedication, surgical treatment plan, treatment, surgery, outcome, complications, postoperative complications, pain management, and analgesia. The initial search was limited to human studies that were published from 1999 to 2009 and indexed as metaanalyses, randomized controlled trials, clinical trials, or comparative studies. Very fe...

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Use of Autologous Platelet Concentrate in Blepharoplasty Surgery

Abstract: Although there were statistically significant differences in edema using autologous platelet gel in blepharoplasty surgery, trends toward improvement in postoperative edema and ecchymosis did not achieve clinical significance.

Cited by 26 publications

References 7 publications

The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds

The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds

Efficacy of Autologous Platelet-rich Plasma Glue in Weight Loss Sequelae Surgery and Breast Reduction: A Prospective Study

An Evidence-Based Approach to Blepharoplasty

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