Use of atropine eye drops for clozapine induced hypersalivation

Comley, Charles; Galletly, Cherrie; Ash, David

doi:10.1046/j.1440-1614.2000.0840f.x

Cited by 13 publications

(15 citation statements)

References 3 publications

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“…Clozapine, an atypical antipsychotic drug claimed to have superior efficacy and to cause fewer motor adverse effects than typical antipsychotics for people with treatment-resistant schizophrenic patients, can cause hypersalivation (Wahlbeck et al, 2000). This may be ameliorated with atropine eye drops (Comley et al, 2000).…”

Section: (4) Drug-related Hypersalivationmentioning

confidence: 99%

Adverse Drug Reactions in the Orofacial Region

Scully

Bagán

2004

Critical Reviews in Oral Biology & Medicine

211

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A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.

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Section: (4) Drug-related Hypersalivationmentioning

confidence: 99%

Adverse Drug Reactions in the Orofacial Region

Scully

Bagán

2004

Critical Reviews in Oral Biology & Medicine

211

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“…3 A few previous case reports have shown topical atropine, an antimuscarinic agent, to be effective in the management of clozapine induced sialorrhea (CIS). [4][5][6] Informed consent was received for publication of the following case material.…”

mentioning

confidence: 99%

Sublingual atropine for the treatment of severe and hyoscine-resistant clozapine-induced sialorrhea

et al. 2013

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“…Comley et al reported one patient with schizophrenia that showed a complete resolution of the sialorrhea that was bothersome mainly during the day that after the use of 1 or 2 eye drops of sublingual atropine 1%. They did not mention any side effects.…”

Section: Resultsmentioning

confidence: 99%