Use of ATR-FTIR for detection ofSalmonella typhiinfection in human blood sera

Naseer, K.A.; Ali, Salmann; Mubarik, Sumaira; Hussain, Syed Zajif; Qazi, Javaria

doi:10.1016/j.infrared.2020.103473

Cited by 9 publications

(2 citation statements)

References 13 publications

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“…A conjunction of ATR spectroscopy and multivariate modeling techniques has found applications in molecular fingerprinting of disease development, including of breast, brain, and ovarian cancers [ 11 – 16 ]. Classification has been reported of sera samples from patients with Salmonella [ 17 ] or viral infections [ 18 – 20 ]. Serum spectra were also used to determine levels of total protein [ 21 ], glycated albumin [ 22 ], lipidic parameters [ 23 , 24 ], and glucose [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis

Kokot

Mazurek

Piwowar

et al. 2022

Oxidative Medicine and Cellular Longevity

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Endometriosis is one of the most common gynecological diseases among young women of reproductive age. Thus far, it has not been possible to define a parameter that is sensitive and specific enough to be a recognized biomarker for diagnosing this disease. Nonspecific symptoms of endometriosis and delayed diagnosis are impulses for researching noninvasive methods of differentiating endometriosis from other gynecological disorders. We compared three groups of individuals in our research: women with endometriosis (E), patients suffering from other gynecological disorders (nonendometriosis, NE), and healthy women from the control group (C). Partial least squares discriminant analysis (PLS-DA) models were developed based on selected serum biochemical parameters, specific regions of the serum’s infrared attenuated total reflectance (FTIR ATR) spectra, and combined data. Incorporating the spectral data into the models significantly improved differentiation among the three groups, with an overall accuracy of 87.5%, 97.3%, and 98.5%, respectively. This study shows that infrared spectroscopy and discriminant analysis can be used to differentiate serum samples among women with advanced endometriosis, women without this disease, i.e., healthy women, and, most importantly, also women with other benign gynecological disorders.

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Section: Introductionmentioning

confidence: 99%

ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis

Kokot

Mazurek

Piwowar

et al. 2022

Oxidative Medicine and Cellular Longevity

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show abstract

“…Furthermore, they provide quick and non-destructive analyses without sample preparation, making it ideal for screening tests. There are numerous examples of biofluid-based RS being used to successfully screen for various cancer types in the literature [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Raman Spectral Characterization of Urine for Rapid Diagnosis of Acute Kidney Injury

Jeng

Sharma

Lee

et al. 2022

JCM

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Acute kidney injury (AKI) is a common syndrome characterized by various etiologies and pathophysiologic processes that deteriorate kidney function. The aim of this study is to identify potential biomarkers in the urine of non-acute kidney injury (non-AKI) and AKI patients through Raman spectroscopy (RS) to predict the advancement in complications and kidney failure. Selected spectral regions containing prominent peaks of renal biomarkers were subjected to partial least squares linear discriminant analysis (PLS-LDA). This discriminant analysis classified the AKI patients from non-AKI subjects with a sensitivity and specificity of 97% and 100%, respectively. In this study, the RS measurements of urine specimens demonstrated that AKI had significantly higher nitrogenous compounds, porphyrin, tryptophan and neopterin when compared with non-AKI. This study’s specific spectral information can be used to design an in vivo RS approach for the detection of AKI diseases.

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ATR-FTIR spectroscopy-based differentiation of hepatitis C and dengue infection in human freeze-dried sera

Ali

Naseer

Hussain

et al. 2021

Infrared Physics & Technology

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Use of ATR-FTIR for detection ofSalmonella typhiinfection in human blood sera

Cited by 9 publications

References 13 publications

ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis

ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis

Raman Spectral Characterization of Urine for Rapid Diagnosis of Acute Kidney Injury

ATR-FTIR spectroscopy-based differentiation of hepatitis C and dengue infection in human freeze-dried sera

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