Use of aspartate aminotransferase in diagnosing periodontal disease: a comparative study of clinical and microbiological parameters

Silva, Emílio Barbosa e; Salvador, S. L.; Fogo, José Carlos; Marcantonio, Rosemary Adriana Chiérici

doi:10.2334/josnusd.45.33

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…The reduced GI value and AST levels indicate that the gingival health has improved [16]. In contrast to these studies, the AST level in the gingival fluid [17] and saliva [18] was not in correlation with the GI and PI values. Similar results have been obtained in our research.…”

Section: Discussioncontrasting

confidence: 81%

Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy

et al. 2021

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Introduction/Objective. Aggressive periodontitis (AP) is a progressive disease that leads damage to periodontal tissues. The aim of the study was the analysis of intracellular enzymes: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), acid phosphatase (ACP) and electrolytes in the saliva of patients with AP and their correlation with clinical parameters before and after the therapy. Methods. The study included 30 patients with AP (experimental group) and 35 patients with healthy parodontium (control group). Intracellular enzymes and electrolytes were analyzed in an unstimulated saliva of subjects with AP, before and after the therapy and in saliva of the control group. The analysis of biochemical markers was carried out using kinetic methods with commercial reagents. Results. Concentrations of the biochemical markers AST (28.18 ? 25.16), ALT (5.48 ? 5.14), ALP (31.13 ? 37.79), ACP (17.53 ? 14.77), calcium (2.80 ? 1.97), phosphate (4.43 ? 1.92) in the saliva of subjects of the experimental group were statistically significantly higher in relation to the control group (p = 0.000; p = 0.001). Significant correlation was found between AST values, debris index (? = -0.444; p = 0.026) and calculus index (? = -0.513; p = 0.009), and between the plaque index and ALP level in the saliva after therapy (p = 0.020). Conclusion. The investigation will contribute to a better understanding and standardization of biomarkers in the saliva that mayhelp in diagnosing the AP and evaluation of the applied therapy.

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Section: Discussioncontrasting

confidence: 81%

Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy

et al. 2021

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“…Thus, the enhanced development in the levels of AST is present in the GCF of diseased sites in comparison to healthy sites. These are active sites of periodontal tissues [ 44 ]. So, it is hypothesized that during gingival inflammation, its concentration will be increased, and after the SRP, when the microbial load is reduced, AST levels in periodontitis may also be decreased [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial

Eldessouky,

Marie

2024

BioMed Research International

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Background. Menopause is typically accompanied by significant systemic and oral manifestations, including hormonal changes and increased susceptibility to periodontal disease, which may involve inflammatory biomarkers like aspartate aminotransferase (AST) and osteocalcin in gingival crevicular fluid (GCF). The study is aimed at evaluating the effectiveness of regular inoculation of polyunsaturated fatty acids (PUFAs) as an adjunctive treatment for menopausal women’s periodontitis. Methods. Twenty elderly women with chronic periodontitis were split evenly into two groups by random assignment. Patients in group II (the research group) were given soft gelatin capsules containing PUFAs to be consumed directly once daily for 12 months, as opposed to group I (the control group), who received soft gelatin capsules containing some olive oil (placebo). Scaling and root planning (SRP) were used to address periodontal disease in all cases. Results. At baseline, six and twelve months after treatment, clinical indicators and AST and osteocalcin amounts in the GCF were noted. By the conclusion of the research period, all observed clinical measurements had changed significantly and improved. In addition, there had been a significant decrease in AST levels and a nonsignificant decrease in osteocalcin levels in group II compared to group I. Conclusions. Menopausal women with periodontitis who take omega-3 fatty acid supplements in addition to SRP have better oral health. Significant improvements in clinical indicators and a notable decrease in AST levels within the GCF were observed. However, further research with larger cohorts and extended duration is needed to validate these findings and explain potential mechanisms. This trial is registered with NCT06254118.

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Salivary biomarkers for predicting the progression of chronic periodontitis

Nomura

Shimada

Hanada

et al. 2012

Archives of Oral Biology

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Use of aspartate aminotransferase in diagnosing periodontal disease: a comparative study of clinical and microbiological parameters

Cited by 7 publications

References 21 publications

Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy

Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy

Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial

Salivary biomarkers for predicting the progression of chronic periodontitis

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