Use of Antisera for Identification of Enterotoxigenic Escherichia Coli

Merson, Michael H.; Black, Robert E.; Gross, R. J.; Rowe, B.; Huq, I.; Eusof, A

doi:10.1016/s0140-6736(80)90118-x

Cited by 45 publications

(29 citation statements)

References 6 publications

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“…LT-producing strains were the commonest ETEC encountered, followed by those producing LT and ST. This observation corroborates earlier findings in Calcutta (Ganguly et al, 1980;Sen et al, 1983) but differs from those obtained in Bangladesh, where ETEC producing both LT and ST were isolated more commonly than those producing only LT or only ST (Sack et al, 1977;Merson et al, 1979;Merson et al, 1980). All the ETEC isolates detected in this study were serotypable and were distributed among eight 0 : K : H groups.…”

Section: Discussionsupporting

confidence: 92%

Studies on Escherichia coli as a cause of acute diarrhoea in calcutta

Sen

Ganguly

Saha

et al. 1984

Journal of Medical Microbiology

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SUMMARY. The prevalence of different types of diarrhoea-producingEscherichia coli among 240 patients with acute diarrhoea in hospital was investigated. The 25 patients (1 0.4% of the total) from whose faeces we isolated enteropathogenic E. coli (EPEC) were all < 5 years old but the 29 (12.1%) from whom we isolated enterotoxigenic E. coli (ETEC) were of various ages, most of them > 12 years old. No enteroinvasive E. coli (EIEC) strains were isolated. ETEC strains that produced heat-labile toxin (LT) were encountered more often than those that produced either heat-stable toxin (ST) alone or both LT and ST. The ETEC isolates were distributed among eight different serotypes, the commonest being 0 148 : H28 (38%). Correlations between enterotoxin production, serotype pattern and possession of colonisation factor antigens I and I1 were observed.

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Section: Discussionsupporting

confidence: 92%

Studies on Escherichia coli as a cause of acute diarrhoea in calcutta

Sen

Ganguly

Saha

et al. 1984

Journal of Medical Microbiology

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“…Screening multiple strains per specimen increases the chance of detecting pathogenic strains but many investigators are unable to do this because of resource limitations, in which case it may be beneficial to screen DNA isolated from stool [248][249][250].…”

Section: Diagnosis Of Diarrheagenic E Coli: What Is It Needed and Homentioning

confidence: 99%

Diarrheagenic Escherichia coli in sub-Saharan Africa: Status, Uncertainties and Necessities

Okeke

2009

J Infect Dev Ctries

121

103

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Diarrhea is a leading cause of illness and death, particularly in developing countries. Enteropathogenic Escherichia coli, enterotoxigenic E. coli (ETEC), enteroinvasive E. coli, enterohemorrhaghic E. coli (EHEC), enteroaggregative E. coli (EAEC) and diffusely adherent E. coli (DAEC) have been associated with diarrheal disease in different parts of Africa, particularly among young children, HIV-positive individuals, and visitors from abroad. Each of these E. coli pathotypes uses distinct mechanisms, which are only partially understood, to colonize infected hosts and produce diarrhea. All known diarrheagenic E. coli pathotypes have been reported from diverse locations within Africa but the true burden from these pathogens is unknown because very few studies seeking these organisms with discriminatory methodology have been performed. Recent reports implicate ETEC and EAEC in a considerable proportion of childhood and travellers' diarrheas and suggest that some sub-types of these categories may have greater epidemiological significance than others. The significant contribution of EHEC to bloody diarrhea and hemolytic uremic syndrome is underappreciated because diagnostic capacity for this pathotype is generally inferior to that for confounders such as Shigella and Entamoeba. Recent studies in Africa have revealed the worrisome emergence of antimicrobial resistance and high asymptomatic carriage rates for diarrheagenic E. coli but bacterial and host factors that predispose to disease, as well as non-human reservoirs, are largely unknown. Future diarrheal disease research needs to focus on broadening the repertoire of pathogens sought in epidemiological surveys to include multiple categories of diarrheagenic E. coli while building capacity to detect these pathogens in local reference laboratories.

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“…Although the ETEC strains also have a wide variety of serotypes, a majority of them can be classified in a relatively small number of bioserotypes (6). It has been suggested that ETEC might be identified by serotyping (7,8).…”

mentioning

confidence: 99%

Changing fecalEscherichia coli flora during travel

Ørskov

Sack

Ørskov

et al. 1984

Eur. J, Clin. Microbiol.

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The Escherichia coli flora of 23 Peace-Corps volunteers were monitored during the first six weeks of their stay in Morocco. Fifteen (65%) had a total of 21 diarrheal episodes, six of which were associated with enterotoxigenic Escherichia coli. Bioserotypes O25:K7:H42, O128:H-, O169:H- and O20H- were found. These or other characteristically enterotoxigenic Escherichia coli bioserotypes were not found in asymptomatic persons, except in one case. In general, the Escherichia coli flora not only changed after the volunteers arrived in Morocco but continued to change during the six weeks of investigation.

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Use of Antisera for Identification of Enterotoxigenic Escherichia Coli

Cited by 45 publications

References 6 publications

Studies on Escherichia coli as a cause of acute diarrhoea in calcutta

Studies on Escherichia coli as a cause of acute diarrhoea in calcutta

Diarrheagenic Escherichia coli in sub-Saharan Africa: Status, Uncertainties and Necessities

Changing fecalEscherichia coli flora during travel

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