Use of Antipyrene and N-Acetyl 4-Amino-antipyrene in the Measurement of Body Water and the Intraluminal Water of the Gastro-intestinal Tract of Living Cattle

Reid, J. T.; Balch, C. C.; Head, M. J.; Stroud, J. W.

doi:10.1038/1791034a0

Cited by 24 publications

(11 citation statements)

References 3 publications

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“…I n similar experiments with cattle it was found that the total water content was slightly underestimated by the AP method because of slow equilibration with the water of the gut contents (Reid et al 1957). Soberman (1950) had earlier suggested that, because of protein binding, it should be assumed that the observed plasma concentration of AP is 93% of the true concentration.…”

Section: Accuracy Of Indirect Methods Of Estimating Body Watermentioning

confidence: 98%

“…No special attention appears to have been given to the fact that the water space appears to be larger for AP than for NAAP, although it is evident from data given by Brodie et al (1951) and was confirmed by Reid et al (1957) in experiments with cattle. Similar water spaces for AP and NAAP were found in human subjects in a postabsorptive state (Talso et al 1955), and at least one report (Pawan, 1956) records a water space for NAAP in man larger than that for AP.…”

Section: Effect Of the Gut Watermentioning

confidence: 98%

“…These findings indicate that NAAP was not metabolized by rabbits during periods of up to 379 min. I n cattle 99.5 rf~ 1.79 yo of injected NAAP was recovered in urine collected during a period of 50 h (Reid, Balch, Head & Stroud, 1957).…”

Section: Fate Of Naap In the Bodymentioning

confidence: 99%

“…For these reasons the simultaneous use of NAAP with either tritium or AP appears to offer special advantages for experiments with herbivorous animals. Reid et al (1957) have shown that this two-marker technique promises to provide a means of determining the amount of water in the gut contents of cattle. For non-herbivorous animals in the postabsorptive state the advantage from use of two markers would be very small.…”

Section: Effect Of the Gut Watermentioning

confidence: 99%

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The use of tritium, of antipyrene and of N-acetyl-4-amino-antipyrene in the measurement of body water in living rabbits

Reid¹,

Balch²,

Glascock³

1958

Br J Nutr

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Section: Accuracy Of Indirect Methods Of Estimating Body Watermentioning

confidence: 98%

Section: Effect Of the Gut Watermentioning

confidence: 98%

Section: Fate Of Naap In the Bodymentioning

confidence: 99%

Section: Effect Of the Gut Watermentioning

confidence: 99%

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The use of tritium, of antipyrene and of N-acetyl-4-amino-antipyrene in the measurement of body water in living rabbits

Reid¹,

Balch²,

Glascock³

1958

Br J Nutr

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“…the concentration of AP in the rumen water varied between 75 and 162% of the concentration in the serum water at the same time. Reid, Balch, Head & Stroud (1957), in a study to compare the use of AP and NAAP for estimating body water in cattle, noted that these compounds were not found in the reticulo-ruminal water in the same concentration as in the blood water. The diffusion of AP into the reticulo-rumen was much more rapid than that of NAAP.…”

mentioning

confidence: 99%

Some problems in the use of antipyrine andN-acetyl-4-aminoantipyrine in the determination of body water in cattle

Whiting¹,

Balch²,

Campling³

1960

Br J Nutr

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An accurate in vivo estimation of the body water of animals would be of great value in many nutritional and physiological studies. In the ruminants a method for the separate measurement of body water of the tissues, tissue spaces and circulatory systems (empty body) and of the water of the gastro-intestinal tract (gut water) would be of additional value. One of the most promising methods for determining body water indirectly is the injection into the blood stream of a non-toxic compound that evenly and rapidly distributes itself throughout all body water, that is transformed in or excreted from all body tissues slowly and uniformly, and that can be conveniently and accurately estimated in blood plasma or other body tissues. Soberman, Brodie, Levy, Axelrod, Hollander & Steele (1949) proposed the use of antipyrine (AP) as such a compound for measuring body water indirectly in man and dogs, and later Brodie, Berger, Axelrod, Dunning, Porosowska & Steele ( 1 9 5 1 )proposed the use of N-acetyl-4-aminoantipyrine (NAAP), as this latter compound did not bind with plasma proteins to the same extent as AP. Kraybill, Hankins & Bitter (195 I ) adapted the AP method for use with cattle and found in a study with thirty animals of varying degrees of fatness that the value for body fat, calculated from body water determined by AP, agreed well with that calculated from specific-gravity measurements. Wellington, Reid, Bratzler & Miller (1956) reported that in twenty cattle determinations of body water by the AP technique and by toluene distillation of the body tissues after slaughter agreed closely.On the other hand, White & MacDonald (1956), using cattle, and MacFarlane, Morris & Howard (1956), using sheep, reported unpredictable occurrences of impossible values when AP was used to measure body water. MacFadden & Richards (1956) and Swanson & Neathery (1956) found that the length of time that feed and water were withheld before the injection of AP had a significant effect on the estimated amount of body water. Garrett, Meyer & Lofgreen (1959) in an experiment with thirty-six steers did not find a significant correlation between body fat determined by the use of AP and that determined by specific-gravity measurements of the ninthtenth-eleventh rib sections. In trials with sheep these authors reported also that the length of time feed and water were withheld before the injection of AP had a marked effect on the estimated body water. Rumen samples from these sheep showed that * Research Branch, Canada Department of Agriculture, on postgraduate transfer of work. the concentration of AP in the rumen water varied between 75 and 162% of the concentration in the serum water at the same time.Reid, Balch, Head & Stroud (1957), in a study to compare the use of AP and NAAP for estimating body water in cattle, noted that these compounds were not found in the reticulo-ruminal water in the same concentration as in the blood water. The diffusion of AP into the reticulo-rumen was much more rapid than that of NAAP. This observation led the aut...

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Alimentary Excretion of Environmental Agents and Unnatural Compounds

Pfeiffer

Hänninen

1977

Comprehensive Physiology

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The sections in this article are: Alimentary Excretion of Organic and Inorganic Substances Salivary Excretion Excretion From Respiratory to Gastrointestinal Tract Transfer of Foreign Compounds Into Gastric Contents Intestinal Excretion Pancreatic Excretion General Mechanisms of Biliary Excretion of Foreign Compounds Alimentary Excretion of Selected Pharmacological Agents Alimentary Excretion of Selected Environmental Agents Enteric Factors that May Modify Alimentary Excretion Mucosal and Hepatic Conjugation Presence of Bile Gut Bacteria and Enterohepatic Circulation Chelating Agents Concluding Remarks

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Use of Antipyrene and N-Acetyl 4-Amino-antipyrene in the Measurement of Body Water and the Intraluminal Water of the Gastro-intestinal Tract of Living Cattle

Cited by 24 publications

References 3 publications

The use of tritium, of antipyrene and of N-acetyl-4-amino-antipyrene in the measurement of body water in living rabbits

The use of tritium, of antipyrene and of N-acetyl-4-amino-antipyrene in the measurement of body water in living rabbits

Some problems in the use of antipyrine andN-acetyl-4-aminoantipyrine in the determination of body water in cattle

Alimentary Excretion of Environmental Agents and Unnatural Compounds

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