“…H 1 -antihistamines are the mainstays in the treatment of allergic disorders, particularly seasonal rhinitis, conjunctivitis, urticaria, dermatitis, and asthma Holgate et al, 2008;Pata et al, 2008). Classical (first-generation) H 1 -antihistamines have much stronger sedative effects, e.g., drowsiness, somnolence, fatigue, impairment of cognitive function, memory, and psychomotor performance than second-generation H 1 -antihistamines (Church et al, 2010).…”