Use of and Adherence to Antiretroviral Therapy in a Large U.S. Sample of HIV-infected Adults in Care, 2007-2008

Beer, Linda; Heffelfinger, James D.; Frazier, Emma L.; Mattson, Christine L.; Roter, Brad; Barash, Elizabeth; Buskin, Susan E.; Rime, Todd E.; Valverde, Eduardo

doi:10.2174/1874613601206010213

Cited by 43 publications

(38 citation statements)

References 55 publications

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“…Given that ARV medication is the cornerstone of any successful HIV program (Gallant et al, 2011), having PHAs access lifesaving ARV treatment in a timely manner optimizes their quality of life and avoids possible complications (Beer et al, 2012). This approach is in addition to meeting other requirements such as socioeconomic and psychological needs (UNAIDS, 2011).…”

Section: Discussionmentioning

confidence: 99%

A systematic review of best practices in HIV care

Maina

Mill

Chaw-Kant

et al. 2016

Journal of HIV/AIDS & Social Services

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Best practices in HIV care have the potential to improve patient outcomes and inform practice. We conducted a systematic review of best practices in HIV care that were published from 2003 to 2013. Practices that demonstrated success in achieving desired results based on their objectives were included in the review. Two themes emerged from the eight articles reviewed: (a) the importance of linking newly diagnosed people living with HIV to care and (b) the role of integrated and comprehensive service provision in improving patient outcomes. Inconsistencies in reporting and arbitrary use of the term "best practices" were hurdles in this review.

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Section: Discussionmentioning

confidence: 99%

A systematic review of best practices in HIV care

Maina

Mill

Chaw-Kant

et al. 2016

Journal of HIV/AIDS & Social Services

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“…18–21 Examinations of the prevalence and predictors of ART discontinuation have demonstrated that certain patients are more likely to discontinue ART. Substance use, 22 injection drug use, 23 disease severity, 14,22,24,25 younger age, 14,25,26 racial/ethnic minorities, 26,27 female gender, 22,28 unemployment, 28 perceived HIV stigma, 29 fear of discrimination, 30 mental health, 14,24,28,31,32 and side effects 33 have been associated with ART discontinuation.…”

Section: Introductionmentioning

confidence: 99%

Discontinuation of Antiretroviral Therapy Among Adults Receiving HIV Care in the United States

Hughes

Mattson

Scheer

et al. 2014

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background Continuous antiretroviral therapy (ART) is important for maintaining viral suppression. This analysis estimates prevalence of and reason for ART discontinuation. Methods Three-stage sampling was used to obtain a nationally representative, cross-sectional sample of HIV-infected adults receiving HIV care. Face-to-face interviews and medical record abstractions were collected from June 2009 to May 2010. Data were weighted based on known probabilities of selection and adjusted for nonresponse. Patient characteristics of ART discontinuation, defined as not currently taking ART, stratified by provider-initiated versus non–provider-initiated discontinuation, were examined. Weighted logistic regression models predicted factors associated with ART discontinuation. Results Of adults receiving HIV care in the United States who reported ever initiating ART, 5.6% discontinued treatment. Half of those who discontinued treatment reported provider-initiated discontinuation. Provider-initiated ART discontinuation patients were more likely to have a nadir CD4 ≥200 cells per cubic millimeter. Non–provider-initiated ART discontinuation patients were more likely to have unmet need for supportive services and to have not received HIV care in the past 3 months. Among all patients who discontinued, younger age, female gender, not having continuous health insurance, incarceration, injection drug use, nadir CD4 count ≥200 cells per cubic millimeter, unmet need for supportive services, no care in the past 3 months and HIV diagnosis ≥5 years before interview were independently associated with ART discontinuation. Conclusions These findings inform development of interventions to increase ART persistence by identifying groups at increased risk of ART discontinuation. Evidence-based interventions targeting vulnerable populations are needed and are increasingly important as recent HIV treatment guidelines have recommended universal ART.

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“…Significant advances in the pharmacological properties of antiretroviral therapy (ART) have resulted in decreased side effects and once-daily pill-taking options, significantly reducing treatment burden. Despite these improvements, treatment adherence and retention remain a chronic problem for some people living with HIV (PLWH; Beer et al, 2012; Castro, Santiago, Jiménez, Dávila-Vargas, & Rosal, 2015). …”

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confidence: 99%

Development of a Conceptual Etiological Model of Treatment Regimen Fatigue Among Patients Engaged in HIV Care: A Qualitative Study

Claborn¹,

Miller²,

Meier³

et al. 2017

Journal of the Association of Nurses in AIDS Care

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Treatment regimen fatigue (TRF) is a decreased desire and motivation to maintain vigilance in adhering to treatment, and little is known about TRF in people living with HIV. We aimed to develop a conceptual framework of TRF. Five focus groups were conducted in 2014. Eligible participants were (a) HIV-infected, (b) at least 18 years of age, (c) prescribed antiretroviral therapy, and (d) fluent in English. Data were analyzed using thematic analysis. Analyses revealed these themes: patient experiences of TRF; etiological factors at the systems, provider, and patient levels; strategies to manage TRF; consequences of TRF; and protective factors that prevent the occurrence of TRF. The results provided a conceptual framework for future investigations to build on in an effort to improve adherence and retention in HIV care. Study results indicate avenues for intervention at multiple levels (systems, provider, and patient) to reduce treatment burden and improve patient resources and capacity.

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Use of and Adherence to Antiretroviral Therapy in a Large U.S. Sample of HIV-infected Adults in Care, 2007-2008

Cited by 43 publications

References 55 publications

A systematic review of best practices in HIV care

A systematic review of best practices in HIV care

Discontinuation of Antiretroviral Therapy Among Adults Receiving HIV Care in the United States

Development of a Conceptual Etiological Model of Treatment Regimen Fatigue Among Patients Engaged in HIV Care: A Qualitative Study

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