Use of an Italian version of the telephone interview for cognitive status in Alzheimer's disease

Forno, Gloria Dal; Chiovenda, Paola; Bressi, Federica; Ferreri, Florinda; Grossi, Enzo; Brandt, Jason; Rossini, Paolo Maria; Pasqualetti, Patrizio

doi:10.1002/gps.1435

Cited by 51 publications

(59 citation statements)

References 28 publications

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“…Cholinergic systems have been implicated in several important brain functions, including cortical arousal, sleep-wake cycles, visual information processing, learning, memory, and other cognitive functions. Alzheimer's disease has also been associated at least in part with the loss of cortical cholinergic innervation (Dal Forno et al 2006;Ferreri et al 2003Ferreri et al , 2011bSquitti et al 2007) and SAI abnormalities (Di Lazzaro et al 2005a) and therefore detailed information about the effects of cholinergic innervation on the functioning of cortical circuits is needed if we are to understand the cellular mechanisms underlying the behavioral and cognitive symptoms encountered in that disease.…”

Section: Resultsmentioning

confidence: 99%

Human brain cortical correlates of short-latency afferent inhibition: a combined EEG–TMS study

Ferreri

Ponzo

Hukkanen

et al. 2012

Journal of Neurophysiology

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When linking in time electrical stimulation of the peripheral nerve with transcranial magnetic stimulation (TMS), the excitability of the motor cortex can be modulated to evoke clear inhibition, as reflected by the amplitude decrement in the motor-evoked potentials (MEPs). This specific property, designated short-latency afferent inhibition (SAI), occurs when the nerve-TMS interstimulus interval (ISI) is approximately 25 ms and is considered to be a corticothalamic phenomenon. The aim of the present study was to use the electroencephalographic (EEG) responses to navigated-TMS coregistration to better characterize the neuronal circuits underlying SAI. The present experimental set included magnetic resonance imaging (MRI)-navigated TMS and 60-channel TMS-compatible EEG devices. TMS-evoked EEG responses and MEPs were analyzed in eight healthy volunteers; ISIs between median nerve and cortical stimulation were determined relative to the latency of the individual N20 component of the somatosensory-evoked potential (SEP) obtained after stimulation of the median nerve. ISIs from the latency of the N20 plus 3 ms and N20 plus 10 ms were investigated. In all experimental conditions, TMS-evoked EEG responses were characterized by a sequence of negative deflections peaking at approximately 7, 44, and 100 ms alternating with positive peaks at approximately 30, 60, and 180 ms post-TMS. Moreover, ISI N20+3 ms modulated both EEG-evoked activity and MEPs. In particular, it inhibited MEP amplitudes, attenuated cortical P60 and N100 responses, and induced motor cortex beta rhythm selective decrement of phase locking. The findings of the present experiment suggest the cortical origin of SAI that could result from the cortico-cortical activation of GABAergic-mediated inhibition onto the corticospinal neurons modulated by cholinergic activation able to reducing intralaminar inhibition and promoting intracolumnar inhibition.

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Section: Resultsmentioning

confidence: 99%

Human brain cortical correlates of short-latency afferent inhibition: a combined EEG–TMS study

Ferreri

Ponzo

Hukkanen

et al. 2012

Journal of Neurophysiology

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“…Cognitive impairment was examined primarily by means of a telephone version of the MMSE [22] . Although telephone interviews for measuring cognitive status are now frequently being used in studies of the elderly and have proved reliable and valid in this context [22,37,38] , the conditions of the telephone survey deviate from those at the baseline examination and thus may limit the comparability of the cognitive performance over time. In addition, cognitive impairment was represented in the follow-up by different criteria.…”

Section: Discussionmentioning

confidence: 99%

High Risk of Cognitive and Functional Decline after Postoperative Delirium

Bickel¹,

Gradinger

Kochs

et al. 2008

Dement Geriatr Cogn Disord

262

168

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Background/Aims: The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. Methods: Hip surgery patients aged 60 years or over (n = 200) underwent preoperative and daily postoperative assessment of their cognitive status during hospital stay. Outcome variables were determined at an average of 8 and 38 months after discharge from hospital. Results: Fourty-one patients developed postoperative delirium. Delirium was a strong independent predictor of cognitive impairment and the occurrence of severe dependency in activities of daily living. The associations were more marked for the long- than for the short-term outcome. Thirty-eight months after discharge from hospital, 53.8% of the surviving patients with postoperative delirium suffered from cognitive impairment, as compared to only 4.4% of the nondelirious participants. Logistic regression analysis adjusted for age, sex, medical comorbidity and preoperative cognitive performance revealed highly significant associations between delirium and cognitive impairment (OR = 41.2; 95% CI = 4.3–396.2), subjective memory decline (OR = 6.2; 95% CI = 1.5–25.8) and incident need for long-term care (OR = 5.6; 95% CI = 1.6–19.7). Conclusion: The present study confirms a poor prognosis after delirium in elderly patients. The findings suggest that delirium does not simply persist for a certain time but also predicts a future cognitive decline with an increased risk of dementia.

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“…Dies hat Vorteile in der Verlaufsbeobachtung von Personen mit sehr guter kognitiver Fähigkeit, aber auch in der statistischen Behandlung aggregierter Daten. Die vielfach beschriebene enge Korrelation zwischen MMST und modifizierter Fassung des TICS [5,17] …”

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Matrisch

Trampisch²,

Klaaßen-Mielke³

et al. 2011

Z Gerontol Geriat

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Use of an Italian version of the telephone interview for cognitive status in Alzheimer's disease

Abstract: The I-TICS is a valid instrument in clinical and research screening and monitoring of AD. Potential applications in other dementias and MCI are worth further studies.

Cited by 51 publications

References 28 publications

Human brain cortical correlates of short-latency afferent inhibition: a combined EEG–TMS study

Human brain cortical correlates of short-latency afferent inhibition: a combined EEG–TMS study

High Risk of Cognitive and Functional Decline after Postoperative Delirium

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