Use of an Autologous Vein Graft and Stent in the Repair of Common Bile Defects: An Experimental Study

Abstract

We investigated the effectiveness of using an autologous vein graft and stent in the repair of large defects of the common bile duct (CBD) in a canine model. A 3-cm segment of the vena cephalica antibrachii and a 2-cm segment of the CBD were removed from eight healthy mongrel dogs with normal blood biochemistry levels. A stent was passed through the vein segment, and one end was introduced into the proximal end of the CBD while the other end was introduced into the distal end. The venous graft was then sutured to the CBD. A liver biopsy was taken for histopathological examination during laparotomy and relaparotomy. Blood samples were obtained on postoperative days 7, 14, and 20 for biochemical examination. The defect was effectively repaired by the autologous vein graft and stent in 7 dogs, after the exclusion of 1 dog that died of hemorrhage 3 days after the operation. No change in blood biochemistry was observed postoperatively, and no histopathological change in the liver was found in the preoperative or postoperative periods. These findings indicate that the use of an autologous vein graft and stent to repair CBD injuries may be a feasible and alternative method of treatment.

Choledochal tube stenting for decompression of the extrahepatic portion of the biliary tract in dogs: 13 cases (2002–2005)

“…1 Choledochal stenting is not a new concept in veterinary medicine, and there are several case reports [8][9][10][11][12] in the literature. In addition, results of several experimental studies [13][14][15][16][17][18] that used canine models for human biliary disease have been published regarding a variety of stent types. To the authors' knowledge, however, no previous study has evaluated a cohort of cases in which biliary stenting was used as an alternative to biliary rerouting in dogs with naturally occurring EHBO or for augmentation of primary repair of the common bile duct in dogs with traumatic biliary injury.…”

Biliary Tract Reconstruction Using an Autologous Vein Graft in Rats

“…5,6 Previous studies have shown that veins can be successfully used to reconstruct the CBD. [18][19][20][21][22] There is some controversy as to whether this graft can act as a conduit for biliary reepithelialization. It has been documented that in dogs, for example, the vein graft eventually takes on the histologic appearance of bile duct.…”

Rekonstruktion von Gallengangsdefekten mit autologem Veneninterponat und resorbierbarem Stent im Tiermodell: Technik und klinische Bedeutung

“…T-Drainagen erwiesen sich als bedingt geeignet, möglicherweise in Abhängigkeit vom verwendeten Durchmesser. Während Wittrin [30] über hartnäckige Inkrustierungen der Drainagen berichtete, führte deren Einsatz bei Ulin [28] [9], begünstigt durch die Vorspannung des Stents, mit der das Interponat in das umgebende Gewebe gedrückt wird. Durch die offensichtlich ausreichende Neo-Angiogenese und die geringen entzündlichen Reaktionen sind die Voraussetzungen für das beobachtete stenosefreie Einheilen der Vene und die Langzeitprognose günstig.…”