Use of amplitude-integrated electroencephalography (aEEG) and near infrared spectroscopy findings in neonates with asphyxia during selective head cooling

Gücüyener, Kıvılcım; Beken, Serdar; Ergenekon, Ebru; Soysal, Şebnem; Hırfanoğlu, İbrahim Murat; Turan, Özden; Ünal, Sezin; Altuntaş, Nilgün; Kazancı, Ebru; Kulalı, Ferit; Koç, Esin; Türkyılmaz, Canan; Önal, Esra; Atalay, Yıldız

doi:10.1016/j.braindev.2011.06.005

Cited by 34 publications

(17 citation statements)

References 28 publications

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“…In contrast, Shellhaas et al [16] and Gucuyener et al [17] reported that ScO 2 did not significantly correlate with an adverse outcome (Table 3). Moreover, ScO 2 appears to be only moderately sensitive to cerebral metabolic disturbances occurring in the first few days after birth [18].…”

Section: Discussionmentioning

confidence: 87%

Simultaneous measurement of cerebral hemoglobin oxygen saturation and blood volume in asphyxiated neonates by near-infrared time-resolved spectroscopy

Nakamura

Koyano

Jinnai

et al. 2015

Brain and Development

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Section: Discussionmentioning

confidence: 87%

Simultaneous measurement of cerebral hemoglobin oxygen saturation and blood volume in asphyxiated neonates by near-infrared time-resolved spectroscopy

Nakamura

Koyano

Jinnai

et al. 2015

Brain and Development

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“…However not all reported better test characteristics at 6 h than earlier with Shany et al (2006) reporting the sensitivity of burst suppression at 3 h to be 83% and at 6 h to be 75%. Hallberg et al, 2010;Thoresen et al, 2010;Ancora et al, 2011;Hamelin et al, 2011;Nash et al, 2011;Gucuyener et al, 2012;Csek} o et al, 2013) used hypothermia in their HIE management. Letter 'b' and 'a' after the year of publication in the forest plots indicate the measure before and after cooling respectively of the same study.…”

Section: Issues Relating To the Definitions Of Abnormal Patternsmentioning

confidence: 99%

EEG background features that predict outcome in term neonates with hypoxic ischaemic encephalopathy: A structured review

Awal

Lai

Azemi

et al. 2016

Clinical Neurophysiology

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“…However, obtaining MRI scans in critically ill newborns, is logistically challenging, expensive and not widely available. Near-infrared spectroscopy (NIRS) might prove to be an attractive alternative (Ancora et al, 2009, 2011; Grant et al, 2009; Gucuyener et al, 2012; Toet et al, 2006; Toet and Lemmers, 2009; Wolfberg and du Plessis, 2006), as it permits continuous bedside monitoring of cerebral hemodynamics and oxygenation, by measuring changes in the concentration of oxygenated and deoxygenated hemoglobin (Marin and Moore, 2011; Meek et al, 1999; Pellicer and del Carmen Bravo, 2011; Soul and du Plessis, 1999; Wyatt, 1993). It thus does not provide direct measurement of CBF in different brain regions, but records regional mixed venous saturation (SctO2), which are representative of oxygen supply/demand ratio.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic–ischemic encephalopathy treated with hypothermia

et al. 2014

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Background The measurement of brain perfusion may provide valuable information for assessment and treatment of newborns with hypoxic-ischemic encephalopathy (HIE). While arterial spin labeled perfusion (ASL) magnetic resonance imaging (MRI) provides noninvasive and direct measurements of regional cerebral blood flow (CBF) values, it is logistically challenging to obtain. Near-infrared spectroscopy (NIRS) might be an alternative, as it permits noninvasive and continuous monitoring of cerebral hemodynamics and oxygenation at the bedside. Objective The purpose of this study is to determine the correlation between measurements of brain perfusion by NIRS and by MRI in term newborns with HIE treated with hypothermia. Design/Methods In this prospective cohort study, ASL-MRI and NIRS performed during hypothermia were used to assess brain perfusion in these newborns. Regional cerebral blood flow values (CBF), measured from 1–2 MRI scans for each patient, were compared to mixed venous saturation values (SctO2) recorded by NIRS just before and after each MRI. Analysis included groupings into moderate versus severe HIE based on their initial background pattern of amplitude-integrated electroencephalogram. Results Twelve concomitant recordings were obtained of seven neonates. Strong correlation was found between SctO2 and CBF in asphyxiated newborns with severe HIE (r = 0.88; p value = 0.0085). Moreover, newborns with severe HIE had lower CBF (likely lower oxygen supply) and extracted less oxygen (likely lower oxygen demand or utilization) when comparing SctO2 and CBF to those with moderate HIE. Conclusions NIRS is an effective bedside tool to monitor and understand brain perfusion changes in term asphyxiated newborns, which in conjunction with precise measurements of CBF obtained by MRI at particular times, may help tailor neuroprotective strategies in term newborns with HIE.

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Use of amplitude-integrated electroencephalography (aEEG) and near infrared spectroscopy findings in neonates with asphyxia during selective head cooling

Cited by 34 publications

References 28 publications

Simultaneous measurement of cerebral hemoglobin oxygen saturation and blood volume in asphyxiated neonates by near-infrared time-resolved spectroscopy

Simultaneous measurement of cerebral hemoglobin oxygen saturation and blood volume in asphyxiated neonates by near-infrared time-resolved spectroscopy

EEG background features that predict outcome in term neonates with hypoxic ischaemic encephalopathy: A structured review

Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic–ischemic encephalopathy treated with hypothermia

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