Use of Alum to Control Intractable Vesical Haemorrhage

Abstract

Eight patients with hitherto uncontrollable vesical bleeding were treated by irrigating the bladder with a 1% solution of alum. The method does not require anaesthesia and bleeding ceased in every case.

Radiation–Induced Haemorrhagic Cystitis

“…Kennedy et al [41]reported their experience with intravesical alum in 8 patients (7 of whom had received prior radiotherapy for bladder cancer), all of whom continued to bleed after cystodiathermy. A 1% solution of alum was used without anaesthesia.…”

“…Associated aluminium toxicity may [43, 44]or may not occur [41, 44]. Toxicity is manifested as severe encephalopathy, and while this may be reversible, in some cases it is believed to have been a contributing factor in the subsequent death of the patient [44].…”

Treatment of post-hematopoietic stem cell transplantation hemorrhagic cystitis with intravesicular sodium hyaluronate

“…Also, it is known that alumin salts can cause severe allergic reactions in susceptible individuals even after topical use. 16,17 Formalin instillation, one of the most effective treatments for severe HC, requires general anesthesia and is associated with important long-term complications including fibrosis of the bladder, urinary incontinence, papillary necrosis, vesicouretheral reflux and urinary tract obstruction with hydronephrosis. 18,19 Prostaglandins have been reported to have some beneficial effects when administered intravesically.…”

The management of cyclophosphamide‐induced haematuria

“…In early work, eight patients aged 57-82 years and with severe vesical bleeding had irrigation for a mean of 3 days; the bleeding stopped in all of them within this time [37].…”