Use of allogeneic platelet gel in the management of chemotherapy extravasation injuries: a case report

Abstract

The allogeneic platelet (PLT) gel offers to be a valid supportive measure in the management of chemotherapy extravasation injuries. We report a case of a 58-year-old patient with multiple myeloma enrolled for high-dose chemotherapy and autologous stem cell transplantation. As pretransplant therapy, the patient received induction therapy with bortezomib, adriblastina, and desametazone. A port was inserted in the vein on the back of the hand. After three cycles, the patient reported rapid development of redness, pain, and necrotic tissue in the left hand, and a diagnosis of extravasation was addressed. The patient presented a raw area on the back of the hand caused by cytotoxic/chemotherapeutic drug leakage because of the malposition of venous access devices. Skin ulcer was debrided, and the wound was reconstructed with a combination of local random rotational flap and abdomen skin graft. Two weeks later, a 20% skin flap necrosis was observed. In the context of wound healing, topical plasma-rich PLT gel is able to accelerate the regeneration and repair of tissue, so it was set out to assess PLT gel efficacy in this case. The PLT gel was applied topically once every 5 days, for a duration of 60 days on average. There were no adverse reactions observed during the topical therapy. Complete wound healing was observed after 12 PLT-rich plasma applications. No ulcer recurrence was noted in the patient during the follow-up period of 2–19 months.

Homologous platelet gel on radiation-induced dermatitis in a patient receiving head and neck radiotherapy plus cetuximab: A case report

“…[7][8][9][10][11] In line with the biostimulatory role of platelets, several studies have documented the healing properties of platelet concentrates in the treatment of radiodermatitis lesions. [12][13][14][15][16][17] In particular, the use of platelet gel has emerged as a promising new treatment modality for radiodermatitis. This approach involves the utilization of platelet-rich plasma (PRP), a concentrated source of platelets that can be activated by exposure to calcium ions and the addition of thrombin.…”

“…[7–11] In line with the biostimulatory role of platelets, several studies have documented the healing properties of platelet concentrates in the treatment of radiodermatitis lesions. [12–17]…”

Avaliação do processo de reparo tecidual e ação imunomodulatória do plasma rico em plaquetas (PRP) no tratamento de estrias abdominais

“…de plaquetas cinco vezes maior que o valor basal do sangue B) Concentração de plaquetas cinco vezes menor que o valor basal do sangue.O PRP com ativadores de plaquetas para promoção de liberação dos grânulos tem sido muito utilizado na cicatrização de lesões(Costanzo et al, 2015); entretanto, de acordo comMishra et al (2014) a sua utilização sem ativação sugere melhores respostas. Modelos de estudos tanto em animais, quanto em humanos, vêm sendo publicados com a utilização de ambas as técnicas.…”