Use of Alcea rosea leaf extract for biomimetic synthesis of gold nanoparticles with innate free radical scavenging and catalytic activities

Khoshnamvand, Mehdi; Ashtiani, Saeed; Huo, Can; Saeb, Saviz Parsa; Liu, Jingfu

doi:10.1016/j.molstruc.2018.11.079

Cited by 46 publications

(30 citation statements)

References 48 publications

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“…Recent research reports [54,57,58,95] supported the above submission. Au NPs biosynthesized from Halymenia dilatata also demonstrated higher antioxidant activity than the starting plant extract [97].…”

Section: Antioxidant Activity/total Phenolic Contentmentioning

confidence: 54%

“…Hesperidin [43,44], diosmin, and naringin [44], curcumin [45], guavanoic acid [46], phloridzin, an antidiabetic agent found in fruits and its aglycon [47], escin [48], resveratrol [49], and gymnemic acid [50] were found to be responsible for the biosynthesis of Au NPs. Other compounds that have been used in the formation of Au NPs with antidiabetic properties include chitosan, chondroitin sulfate, tyrosine and tryptophan [51][52][53].Like the metal-reducing ability of plant extracts, the antioxidants activity has been associated with the plants' phenolics [54]. Pu and colleagues [55] argued that antioxidants possess free radical scavenging properties, hence, they play role in promoting health and preventing diseases.…”

mentioning

confidence: 99%

“…Like the metal-reducing ability of plant extracts, the antioxidants activity has been associated with the plants' phenolics [54]. Pu and colleagues [55] argued that antioxidants possess free radical scavenging properties, hence, they play role in promoting health and preventing diseases.…”

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confidence: 99%

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Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

et al. 2020

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In this study, procyanidins fractions of dimers and trimers (F1-F2) from the Leucosidea sericea total extract (LSTE) were investigated for their chemical constituents. The total extract and the procyanidins were employed in the synthesis of gold nanoparticles (Au NPs) and fully characterized. Au NPs of 6, 24 and 21 nm were obtained using LSTE, F1 and F2 respectively. Zeta potential and in vitro stability studies confirmed the stability of the particles. The enzymatic activity of LSTE, F1, F2 and their corresponding Au NPs showed strong inhibitory alpha-amylase activity where F1 Au NPs demonstrated the highest with IC 50 of 1.88 µg/mL. On the other hand, F2 Au NPs displayed the strongest alpha-glucosidase activity at 4.5 µg/mL. F2 and F2 Au NPs also demonstrated the highest antioxidant activity, 1834.0 ± 4.7 µM AAE/g and 1521.9 ± 3.0 µM TE/g respectively. The study revealed not only the ability of procyanidins dimers (F1 and F2) in forming biostable and bioactive Au NPs but also, a significant enhancement of the natural products activities, which could improve the smart delivery in future biomedical applications.Biomolecules 2020, 10, 452 2 of 24 applying nanoparticles through the green route is their biocompatibility [5]. Many green synthesized nanoparticles have demonstrated interesting biological activities [5,10] including antimicrobial and antidiabetic properties.Diabetes mellitus has undoubtedly become a serious health challenge. More worrisome is type II diabetes mellitus (T2DM), which accounts for 90% of diabetes mellitus. It occurs as a result of the inefficient processing of insulin [11]. As of 2017, the population of adults between the ages of 20 and 79 that suffered from diabetes was 425 million [12]. This is equivalent to 9.9% of the world's population [12]. By estimation, this disease would have drastically increased by 48% in 28 years if not properly managed [13]. Although drugs like miglitol, vigliobose as well as acarbose are available in the market, they are costly and their continuous use is associated with side effects like diarrhea, dropsy, heart failure, damage to the liver, weight gain, abdominal pain, hyperglycemia, and flatulence, necessitating the need for more potent and newer remedies [14][15][16].It is well established that bioactive compounds in various plants possess significant effects in delaying and management of T2DM [17]. Extracts from different plants have been reported as alpha-glucosidase and alpha-amylase inhibitors [18][19][20][21][22][23][24][25][26][27]. Additionally, biologically synthesized Au NPs using plant extracts showed interesting antidiabetic activity. The extracts of Chamalcostus cuspidatus [28], Gymnema sylvestre [29], Cassia fistula stem bark [30], Hericium erinaceus [31], Turbinaria conoides [32], Sambucus nigra [33] and Sargassum swartzi [34] displayed antidiabetic activities in various investigations. Silver/gold NPs of Ocimum basilicum [35] and cinnamon extract [36] also lowers glucose levels. The use of single molecules as reducing/stabilizing agents for ...

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Section: Antioxidant Activity/total Phenolic Contentmentioning

confidence: 54%

mentioning

confidence: 99%

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Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

et al. 2020

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“…[ 1,2 ] Gold nanoparticles are important nanomaterials and they are widely used in catalysis reactions, biosensor applications, optical‐electronic devices, and some medicinal treatments. [ 3 ] The resistance of microorganisms to unconsciously used antibiotics causes serious problems in the fight against pathogenic microorganisms. Therefore the search for alternative antimicrobial agents is very important.…”

Section: Introductionmentioning

confidence: 99%

“…3H 2 O) and the formation of AuNPs. [ 3,7,8 ] Schematic representation of the synthesis of gold nanoparticles from a waste vegetable source is shown in Figure .…”

Section: Introductionmentioning

confidence: 99%

Determination of Antimicrobial and Toxic Metal Removal Activities of Plant‐Based Synthesized (Capsicum annuumL. Leaves), Ecofriendly, Gold Nanomaterials

2020

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Nanoparticles are valuable materials with widespread use. The fact that these materials are obtained by biological resources with an environmentally friendly method contributes to the development of studies in this field. Gold nanoparticles (AuNPs) from waste vegetable sources (green leaves of Capsicum annum L.) are economically and easily synthesized. The obtained particles are characterized by UV–vis spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and scanning electron microscopy (SEM) analysis. The antimicrobial activity of the particles on the pathogenic microorganisms Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus subtilis bacteria, and Candida albicans yeast are found to have a significant suppressive effect. The removal activities of eight toxic metals (Pd, Cd, Fe, Ni, Co, Mn, Zn, Pb) in Diyarbakır drinking water and artificially prepared water within different pHs are investigated. Gold nanoparticles synthesized from Capsicum annuum L. leaves are found to be effective in toxic metal removal in water samples.

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Heliotropium eichwaldi‐functionalized gold nanoparticles synthesis, characterization, and biological activities

Sher,

Ahmed,

Mushtaq

2024

Applied Organom Chemis

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Nanoparticles (NPs) are the essential building block of nanotechnology; they have a wide range of biomedical applications. In comparison with chemical methods, green synthesis is significant because of their non‐toxicity, eco‐friendliness, and simplicity; thus, the plant extracts are useful in the biogenic synthesis of NPs. In this study, Heliotropium eichwaldi‐induced gold NPs (HE‐AuNPs) were produced. These HE‐AuNPs were afterward examined using UV–vis spectroscopy, FTIR, SEM, XRD, and EDX analysis. The XRD analysis authorized the crystalline structure of AuNPs with an average size of 11.11 nm for four peaks (38.31°, 44.39°, 64.76°, and 77.65°), the SEM analysis displayed the elongated sphere‐shaped morphologies of HE‐AuNPs with 20 nm size, and the EDX analysis revealed that Au (44.33%) was the main element of AuNP. The FTIR analysis confirmed the presence of various coating and reducing organic molecules. In comparison with HE extract and hydrogen tetrachloroaurate (III) trihydrate (HAuCl4.3H2O) solution, the AuNPs showed outstanding inhibitory activity against free radicals, ‐amylase, and AChE. Our work suggests the successful generation of HE‐AuNPs, subsequently significant antioxidant, antidiabetic, and anti‐Alzheimer agents. However, further study is suggested to minimize potential risks.

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Use of Alcea rosea leaf extract for biomimetic synthesis of gold nanoparticles with innate free radical scavenging and catalytic activities

Cited by 46 publications

References 48 publications

Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

Determination of Antimicrobial and Toxic Metal Removal Activities of Plant‐Based Synthesized (Capsicum annuumL. Leaves), Ecofriendly, Gold Nanomaterials

Heliotropium eichwaldi‐functionalized gold nanoparticles synthesis, characterization, and biological activities

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