Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)

Adaş, Gökhan; Arıkan, Soykan; Kemik, Özgür; Öner, Ali; Sahip, Nilgun; Karatepe, Oğuzhan

doi:10.3748/wjg.15.112

Cited by 92 publications

(82 citation statements)

References 22 publications

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“…Cyst rupture can cause anaphylactic shock or may release a large number of viable scoleces that implant elsewhere and produce secondary cysts [30]. Albendazole sulfoxide, albendazole sulfone and combined albendazole sulfoxide and albendazole sulfone mixed together in concentrations of 50 μg/ml of 4%, NaCl 20%, and 1.5% cetrimide -0.15% chlorhexidine (10%) did not provide a marked result as scolicidal agents [31].…”

Section: Discussionmentioning

confidence: 99%

Gluteal region musculoskeletal hydatid cyst: Case report and review of literature

2010

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Hydatid disease is a parasitic infestation of humans and herbivorous animals, caused by Echinococcu granulosus. Dogs and some wild carnivores, like foxes, are definitive hosts, harboring worms in their intestines. Musculoskeletal cysts account for 0.7-3% of total cases of hydatidosis. Primarymuscular hydatidosis without involving the thoracic or abdominal organs is extremely rare. Intramuscular infestation may mimic a soft tissue tumor leading to inappropriate cyst rupture with the attendant risks of anaphylaxis and dissemination to other organs. So preoperative evaluation is critical to avoid lifethreatening complications. We report a case of 34-year-old male patient with a cystic gluteal swelling turning out to be hydatid cyst on surgical exploration. Surgical excision with a pharmacology complementary treatment with antihelementhics is necessary to achieve the complete healing.

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Section: Discussionmentioning

confidence: 99%

Gluteal region musculoskeletal hydatid cyst: Case report and review of literature

2010

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“…10 µg/ml of albendazole solution is enough to completely kill scolices in vitro and the optimal concentration of albendazole for percutaneous injection and drainage is 1.7 µg/ml. This solution has been shown to be effective for treatment in both experimental and clinical studies (Paksoy et al, 2005;Yetim et al, 2005;Adaş et al, 2009). In the present study, we injected scolicidal agent directly into the common bile duct.…”

Section: Discussionmentioning

confidence: 99%

The effects of albendazole-alcohol solution on the hepatobiliary system

Sarp¹,

Amanvermez²,

Polat³

et al. 2012

jecm

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“…The restructuring of the drugs to yield the best formulation can be attempted. Since for no ideal scolicidal agents have been presented (43). In vivo studies have considered the efficacy of albendazole-based combination therapy against echinococcosis.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effects of Artemether, Artemisinine, Albendazole, and Their Combinations on Echinococcus granolosus Protoscoleces

Mohammadnejad

Ghaffarifar

Dalimi

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Hydatidosis caused by Echinococcus granulosusus remains an important parasitic disease, mainly in the Mediterranean region, in human and veterinary medicine. Many protoscolicidal agents have been used to treat it, but most of them are not safe and effective due to their undesirable side effects. Objectives: The aim of the present work was to evaluate the in vitro efficacy of the antihelminths artemether, artemisinine, albendazole, and drug combinations against Echinococcus granulosusus protoscoleces. Materials and Methods: Echinococcus granulosus protoscoleces were aseptically removed from liver hydatid cysts in sheep. Drugs were used at the following final concentrations: 1, 2.5, 5, 10, 25, 50, 100, and 200 μg/mL for 15 days. The viability of protoscoleces was confirmed by Eosine 0.1%. Results: In this case, the protoscolicidal effect of artemether and its combinations was significantly (P < 0.05) higher than other groups; the maximum protoscolicidal effect was found with 200 μg/mL of artemether after 4 days whereas albendazole killed protoscoleces on the 7th day post-incubation. Surprisingly, the incubation of protoscoleces with artemisinine exhibited promising results, as only artemisinine was more effective against evaginated protoscoleces on the 9th day. The maximum effect of two drugs combined belonged to artemether and artemisinine. Conclusions:The obtained outcome demonstrated the desirable effect of artemether against Echinococcus granulosus protoscoleces. With regard to artemisinine's astonishing results, it seems that artemisinine can be a striking drug for tissue and metacestode forms of hydatidosis in human and animal models. However, further investigations into the in vivo experiments are proposed.

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Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)

Abstract: Despite being active, ABZ metabolites did not provide a marked advantage over 20% hypertonic saline. According to these results, we think creating a newly improved and more active preparation is necessary for hydatid cyst treatment.

Cited by 92 publications

References 22 publications

Gluteal region musculoskeletal hydatid cyst: Case report and review of literature

Gluteal region musculoskeletal hydatid cyst: Case report and review of literature

The effects of albendazole-alcohol solution on the hepatobiliary system

In Vitro Effects of Artemether, Artemisinine, Albendazole, and Their Combinations on Echinococcus granolosus Protoscoleces

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