Use of afoxolaner for the treatment of lice (Goniodes pavonis) in different genera (Chrysolophus spp, Lophura spp, Phasianus spp, and Syrmaticus spp) and species of pheasants and West Mexican Chachalacas (Ortalis poliocephala)

Jaramillo, Enrique Yarto; Núñez, Camilo Romero; Zavala, María de los Á. Álvarez; López, Eduardo Cruz; Díaz, Josué Rangel; Contreras, Laura Miranda; Franco, Evelyn Galicia; Heredia, Rafael

doi:10.1016/j.vetpar.2020.109065

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Similarly, a recent study demonstrated the efficacy of afoxolaner against T. canis in dogs [12]. As previously shown [12], off-label afoxolaner was demonstrated to have a very high to maximum efficacy also against lice in birds [20,21]. Another isoxazoline, fluralaner presented an efficacy of 85.1% to 100% against Linognathus setosus in dogs with follow-ups done on days 1, 7, 28 and 84 [10].…”

Section: Discussionmentioning

confidence: 64%

Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo^®) against natural infestations with the cat louse, Felicola subrostratus under field conditions

et al. 2022

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Felicola subrostratus is the only species of louse affecting domestic cats. Although it is considered a rare ectoparasite of pet cats, it occurs mainly in stray or shelter animals and is sometimes associated with intense pruritus and secondary bacterial infections. The aim of the present study was to evaluate the efficacy of a single dose of the topical formulation of esafoxolaner, eprinomectin and praziquantel (NexGard Combo®, Boehringer Ingelheim) in cats for the treatment of naturally acquired chewing lice infestation in a multi-site, positive-control, blinded clinical field study. Thirty-one domestic cats presenting natural F. subrostratus infestation were included in the study. The animals had not been treated with any ectoparasiticide within the previous 60 days. After inclusion, each cat was randomly assigned to one of the two groups: group 1, 14 cats treated with NexGard Combo® or group 2, 17 cats treated with Frontline Combo®. A clinical evaluation was performed at days 0 (inclusion), 14 and 30 and consisted in scoring the skin lesions and symptoms and scoring the presence of lice. On day 30, all cats from both groups scored 0 for the presence of live lice and no dead lice were found, demonstrating 100% efficacy. The clinical scores significantly improved from day 0 to day 30 in both groups. During the 30 days of surveillance, no reinfestations due to the hatching of eggs were observed and none of the cats had any adverse reactions. Esafoxolaner demonstrated high efficacy for the treatment of F. subrostratus infestation.

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Section: Discussionmentioning

confidence: 64%

Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo^®) against natural infestations with the cat louse, Felicola subrostratus under field conditions

et al. 2022

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“…The present study is the first to evaluate the efficacy of an isoxazoline, afoxolaner, against T. canis in dogs and the first to evaluate the efficacy of afoxolaner against mammalian lice. Afoxolaner has previously been evaluated in off-label clinical studies against the chewing louse Goniodes pavonis in captive aviary birds, where it demonstrated a 100% efficacy at 28 days post-treatment in various species of pheasants [ 33 ] and an 86.6% efficacy in peacocks [ 34 ]. Kohler-Aanesen et al [ 23 ] reported an efficacy of 85.1% on day 1, 96.8% on day 7 and 100% on days 28 and 84 for an oral formulation of fluralaner against the dog sucking louse Linognathus setosus .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of afoxolaner (NexGard®) against natural infestations with Trichodectes canis in dogs under field conditions

et al. 2022

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Background Trichodectes canis is a small chewing louse found globally that primarily infests dogs. Limited information is available on the efficacy of isoxazolines against infestation with the chewing louse. In the present study, we evaluated the efficacy of afoxolaner, an isoxazoline class compound, in naturally infested domestic dogs. Methods The field study was carried out in Romania. Between September 2021 and December 2021, 43 dogs with confirmed T. canis infestation were included in the study. On the day of the inclusion (day 0), each animal was clinically examined and randomly treated with a control product labeled for use against lice [fipronil-(S)-methoprene combination (Frontline Combo®; Boehringer Ingelheim)] or with the investigational product [chewable tablets containing afoxolaner (NexGard®; isoxazoline)]. Each animal was evaluated for the presence of lice at 15 and 30 days post-inclusion. Results Of the 48 dogs initially included in the study, 43 completed the treatment period [18 in the control group (CG) and 25 in the investigational group (IG)]. At day 14, no living T. canis lice were detected on the dogs in either group. At day 14, dead lice were detected in four dogs in the IG, while eggs were present in two dogs in the IG and in one dog in the CG. At day 30, no lice were detected in either group, while eggs were still present in one dog in the CG. Conclusion These results suggest that afoxolaner is a feasible treatment option against chewing lice in dogs, providing 100% curative efficacy. Graphical Abstract

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Efficacy and innocuity of lotilaner in the treatment of otodectic mange in ferrets

Legain,

Idee,

Mardini

et al. 2024

Veterinary Parasitology

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Use of afoxolaner for the treatment of lice (Goniodes pavonis) in different genera (Chrysolophus spp, Lophura spp, Phasianus spp, and Syrmaticus spp) and species of pheasants and West Mexican Chachalacas (Ortalis poliocephala)

Cited by 3 publications

References 10 publications

Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo^®) against natural infestations with the cat louse, Felicola subrostratus under field conditions

Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo^®) against natural infestations with the cat louse, Felicola subrostratus under field conditions

Efficacy of afoxolaner (NexGard®) against natural infestations with Trichodectes canis in dogs under field conditions

Efficacy and innocuity of lotilaner in the treatment of otodectic mange in ferrets

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Use of afoxolaner for the treatment of lice (Goniodes pavonis) in different genera (Chrysolophus spp, Lophura spp, Phasianus spp, and Syrmaticus spp) and species of pheasants and West Mexican Chachalacas (Ortalis poliocephala)

Cited by 3 publications

References 10 publications

Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo®) against natural infestations with the cat louse, Felicola subrostratus under field conditions

Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo®) against natural infestations with the cat louse, Felicola subrostratus under field conditions

Efficacy of afoxolaner (NexGard®) against natural infestations with Trichodectes canis in dogs under field conditions

Efficacy and innocuity of lotilaner in the treatment of otodectic mange in ferrets

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Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo^®) against natural infestations with the cat louse, Felicola subrostratus under field conditions

Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo^®) against natural infestations with the cat louse, Felicola subrostratus under field conditions