Use of advance information for complex movements in Parkinson’s disease

Weiss, Peter H.; Stelmach, G. E.; Chaiken, A.; Adler, Cameron

doi:10.1016/s1353-8020(99)00008-5

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…Furthermore, these findings suggest that patients with PD are well able to select an appropriate (distal) motor program for their prehension movements to adjust for a (visually) cued change in load. This is in line with previous data showing a preserved ability of patients with PD to use advance information to modify their prehension movements [21]. Thus, the current data indicate that patients with PD are capable of adjusting their grip forces, i. e., a distal component of prehension movements realized by the fingers, to accommodate cued changes in object load.…”

Section: Discussionsupporting

confidence: 92%

“…Studies of prehension movements in Parkinson's disease (PD) [8,21] revealed that patients with PD generate abnormally high grip forces and require more time to complete a lift, particularly with lighter loads. These symptoms are thought to reflect an impairment in the rate of force development [7] that may be -at least in part -restored by deep brain stimulation of the subthalamic nucleus (STN-DBS, [6]).…”

Section: Introductionmentioning

confidence: 99%

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Distal and proximal prehension is differentially affected by Parkinson‘s disease

et al. 2009

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Prehension movements consist of distal (grasp) and proximal (reach, lift) components. The proximal lifting movements (achieved at the wrist) of patients with Parkinson's disease (PD) are characterized by bradykinesia. With respect to the distal component, PD patients show pathologically high grip forces (generated by the fingers) and slowing of force development indicative of disturbed sensorimotor adjustments during prehension. Combining kinematic and force analyses of prehension movements, we investigated whether PD differentially affects the adjustments of the distal or proximal prehension components to current load conditions. First, PD patients (n = 12) and healthy, age-matched control subjects grasped and lifted light and heavy objects without any load cues. Then, they were presented with cues that indicated changes in object load. These load cues were either consciously perceived or rendered subconscious through use of the technique of metacontrast masking. Consistent with the functional organization of the basal ganglia, patients with PD could adapt distal prehension components (grip force) to current load conditions using both types of cues. However, they were impaired in adjusting proximal prehension components (lift velocity). While controls were able to normalize lift velocity with the help of both conscious and subconscious load cues, the PD patients could use neither form of cue, and retained a pathological overshoot in lift velocity. Our results demonstrate that visuomotor integration during prehension movements differs at distal and more proximal joints and that deficits in this integration are pronounced for the latter in Parkinson's disease.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Distal and proximal prehension is differentially affected by Parkinson‘s disease

et al. 2009

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“…Nevertheless, we do intend to imply that the process is at a "higher" level of motor programming rather than a "lower" level of movement execution. In support of this suggestion, Weiss, Stelmach, Chaiken, and Adler (1999) have found that patients with Parkinson's disease are able to use advance information but do suffer from a slowing of the motor preparation process (a slowing that becomes more pronounced in complex tasks like prehension).…”

Section: Discussionmentioning

confidence: 85%

The Preparation of Reach-To-Grasp Movements in Adults, Children, and Children with Movement Problems

Mon-Williams

Tresilian

Bell

et al. 2005

The Quarterly Journal of Experimental Psychology Section A

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This study explored the use of advance information in the control of reach-to-grasp movements. The paradigm required participants to reach and grasp illuminated blocks with their right hand. Four target blocks were positioned on a table surface, two each side of the mid-saggital plane. In the complete precue condition, advance information precisely specified target location. In the partial precue condition, advance information indicated target location relative to the midsaggital plane (left or right). In the null condition, the advance information was entirely ambiguous. Participants produced fastest responses in the complete precue condition, intermediate response times in the partial condition, and the slowest responses in the null condition. This result was observed in adults and four groups of children including a group aged 4-6 years. In contrast, children with Developmental Coordination Disorder (DCD, n=11, aged 7--13 years) showed no advantage of partial precueing. Movement duration was determined by target location but was unaffected by precue condition. Movement duration was a clear function of age apart from children in the DCD group who showed equivalent movement times to those of the youngest children. These findings provide important insights into the control of reach-to-grasp movements and highlight that partial cues are exploited by children as young as 4 years but are not used in situations of abnormal development.

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“…These simple tasks may not be challenging enough to cause obvious variations in RT measurements in patients, leading to inconsistent results. In agreement with this view, studies that used complex tasks requiring the generation of goal‐directed movements are the ones to show that PD patients are able to use advance information about the characteristics of the upcoming movement (Girotti et al ., 1986; Stelmach et al ., 1986; Weiss et al ., 1999). The results of the present study confirm and extend this observation.…”

Section: Discussionmentioning

confidence: 99%

The basal ganglia network mediates the planning of movement amplitude

Desmurget¹,

Grafton²,

Vindras³

et al. 2004

Eur J of Neuroscience

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This study addresses the hypothesis that the basal ganglia (BG) are involved speci®cally in the planning of movement amplitude (or covariates). Although often advanced, based on observations that Parkinson's disease (PD) patients exhibit hypokinesia in the absence of signi®cant directional errors, this hypothesis has been challenged by a recent alternative, that parkinsonian hypometria could be caused by dysfunction of on-line feedback loops. To re-evaluate this issue, we conducted two successive experiments. In the ®rst experiment we assumed that if BG are involved in extent planning then PD patients (who exhibit a major dysfunction within the BG network) should exhibit a preserved ability to use a direction precue with respect to normals, but an impaired ability to use an amplitude precue. Results were compatible with this prediction. Because this evidence did not prove conclusively that the BG is involved in amplitude planning (functional de®cits are not restricted to the BG network in PD), a second experiment was conducted using positron emission tomography (PET). We hypothesized that if the BG is important for planning movement amplitude, a task requiring increased amplitude planning should produce increased activation in the BG network. In agreement with this prediction, we observed enhanced activation of BG structures under a precue condition that emphasized extent planning in comparison with conditions that emphasized direction planning or no planning. Considered together, our results are consistent with the idea that BG is directly involved in the planning of movement amplitude or of factors that covary with that parameter.

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Use of advance information for complex movements in Parkinson’s disease

Cited by 6 publications

References 23 publications

Distal and proximal prehension is differentially affected by Parkinson‘s disease

Distal and proximal prehension is differentially affected by Parkinson‘s disease

The Preparation of Reach-To-Grasp Movements in Adults, Children, and Children with Movement Problems

The basal ganglia network mediates the planning of movement amplitude

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