Use of adjuvant radiotherapy at hospitals with and without on‐site radiation services

Abstract

Objective: Cellular therapy is an investigational approach for stroke. Mononuclear cells (MNCs) from the bone marrow reduce neurological deficits in animal stroke models. We determined if autologous MNC infusion was feasible and safe in patients with ischemic stroke. Methods: We conducted an open‐label prospective study of a bone marrow harvest followed by readministration of autologous MNCs in 10 patients, 18 to 80 years old, with acute middle cerebral artery ischemic stroke. Bone marrow was aspirated from the iliac crest, and MNCs were separated at a Good Manufacturing Practices facility and administered intravenously up to a maximum of 10 million cells/kg. The harvest and infusion had to occur between 24 and 72 hours after stroke. Patients were monitored for 6 months. Results: Bone marrow aspiration was successfully completed in all patients. Eight received 10 million cells/kg, and 2 received ≥7 million cells/kg. There were no significant adverse events related to harvest or infusion. Two patients had infarct expansion between enrollment and harvest and underwent hemicraniectomy after cell infusion. One patient died at 40 days due to a pulmonary embolism related to the stroke. There were no study‐related severe adverse events. Median National Institutes of Health Stroke Scale score was 13 before harvest, 8 at 7 days, and 3 at 6 months. At 6 months, all surviving patients had shifted down by at least 1 point on the modified Rankin Scale compared to day 7. Seven of 10 patients achieved a Barthel Index ≥90. Interpretation: This study suggests that a bone marrow harvest and reinfusion of autologous MNCs were safe and feasible in acute stroke patients. ANN NEUROL 2011;

Multimodality therapy for locoregional extrahepatic cholangiocarcinoma

“…Likewise, differentials in the clinical outcomes associated with tertiary centers (e.g. improved late survival at high volume centers39, or increased utilization of adjuvant radiotherapy in institutions with on-site radiotherapy facilities40) may be obscured in pooled registry data.…”

Availability of Advanced Breast Imaging at Screening Facilities Serving Vulnerable Populations

“…[1][2][3] On-site availability of healthcare resources, which probably plays a role in downstream utilization, remains relatively unexplored for cancer care. 4 For breast cancer screening and diagnosis, it is uncertain whether differences in the ready availability of imaging resources beyond mammography contribute to persistent disparities in breast cancer outcomes. 5 Prior studies addressing timeliness of follow-up after abnormal mammography have been limited by a lack of data on the physical availability of advanced breast imaging modalities.…”