Use of Acetaminophen and Nonsteroidal Anti-inflammatory Drugs: A Prospective Study and the Risk of Symptomatic Diverticular Disease in Men

Aldoori, Walid; Giovannucci, Edward; Rimm, Eric B.; Wing, Alvin L.; Willett, Walter C.

doi:10.1001/archfami.7.3.255

Cited by 112 publications

(65 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a casecontrol study in Japan, risk factors for DH included the use of ATDs and NSAIDs, hypertension, diabetes, arteriosclerotic diseases such as ischemic disease mellitus and chronic kidney disease, age ≥ 70 years, obesity [13,15,17,18] . Our study also found higher rates of use for both ATDs and NSAIDs, higher age and male sex, obesity, smoking, alcohol drinking, and arteriosclerotic diseases in patients with colonic DH compared to those with bleeding from other causes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Increase in colonic diverticular hemorrhage and confounding factors

Kinjo¹,

Matsui²,

Hisabe³

et al. 2016

WJGPT

View full text Add to dashboard Cite

AIM:To classify changes over time in causes of lower gastrointestinal bleeding (LGIB) and to identify factors associated with changes in the incidence and characteristics of diverticular hemorrhage (DH). METHODS:A total of 1803 patients underwent colonoscopy for overt LGIB at our hospital from 1995 to 2013. Patients were divided into an early group (EG, 1995(EG, -2006 n = 828) and a late group (LG, 2007(LG, -2013 Author contributions: Kinjo K collected and analyzed the data, and drafted the manuscript; Matsui T designed and supervised the study; Washio M performed the statistical analysisl; Hisabe T, Ishihara H, Maki S, Chuman K, Koga A, Ohtsu K, Takatsu N, Hirai F and Yao K performed the colonoscopy and revised the manuscript for important intellectual content; all authors have read and approved the final version to be published.Institutional review board statement: This study was approved by the institutional review board of Fukuoka University Chikushi Hospital (R15-024) and was conducted in accordance with the Declaration of Helsinki.Informed consent statement: In this study, We do not necessarily need the individual agreement from a study subject. Because this study is retrospective study and based on the ethical guidelines for medical studies intended for people "taken from the human body undergoes No. 12 informed consent procedures was used samples not research". Information about the implementation of this research exposes to Fukuoka University Chikushi Hospital clinical research support Center home page. Conflict-of-interest statement:In connection with this manuscript, there is no Conflict of Interest to be disclosed with any companies.Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at matsui@ fukuoka-u.ac.jp. Participants gave informed consent was not obtained but the presented data are anonymized and risk of identification is low. Retrospective Studybetween patients with and without DH. RESULTS:Older patients (≥ 70 years old) and those with colonic DH were more frequent in LG than in EG (P < 0.01). Patients using ATDs as well as NSAIDs, male sex, obesity (body mass index ≥ 25 kg/m 2 ), smoking, alcohol drinking, and arteriosclerotic diseases were more frequent in patients with DH than in those without. CONCLUSION:Incidence of colonic DH seems to increase with aging of the population, and factors involved include use of ATDs and NSAIDs, male sex, obesity, smoking, alcohol drinking, and arteriosclerotic disease. These factors are of value in handling DH patients. Core tip: Colonic diverticular hemorrhage (DH) is the most frequent cause of lower gastrointestinal bleeding. A rapid increase in the incidence of colonic DH has been seen with the aging population. One reason is the widespread adoption of antithrombotic drugs (ATDs) since the early 2000s, based on guidelines to prevent ischemic heart disease and ischemic cerebrovascular disease. DH is more likely in patients who are older, are men, obesity, use nonsteroidal anti-inf...

show abstract

Section: Discussionmentioning

confidence: 99%

“…Most NSAIDs inhibit prostaglandin synthesis, which disrupts the microcirculation and inhibits platelet aggregation. As a result, NSAIDs can lead to bleeding in patients with diverticulosis [17] . DH in Japan is more common in men, whereas in Western countries, DH occurs equally in men and women [21] .…”

Section: Peer-reviewmentioning

confidence: 99%

Increase in colonic diverticular hemorrhage and confounding factors

Kinjo¹,

Matsui²,

Hisabe³

et al. 2016

WJGPT

View full text Add to dashboard Cite

show abstract

“…Although acetaminophen has been associated with dyspepsia (33)(34)(35)(36)(37), it is perceived by physicians as not GI toxic (5,38) and, therefore, GPAs are not coprescribed with acetaminophen for gastroprotection. In this study, coprescriptions of GPAs with acetaminophen were considered as baseline prescriptions not related to acetaminophen use.…”

Section: Introductionmentioning

confidence: 99%

Use of NSAIDs, COX‐2 inhibitors, and acetaminophen and associated coprescriptions of gastroprotective agents in an elderly population

Rahme

Marentette

Kong

et al. 2002

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Recent data have also implicated these agents in diverticular bleeding (95,96). Whether patients with diverticulosis should be counseled to avoid NSAIDs, as is done for ulcer patients, is still conjecture, as is the potential role of selective COX-2 antagonist NSAIDs.…”

Section: Hemorrhagementioning

confidence: 99%