“…The criteria to start biological treatment and the follow-up periods differ from validated treat to target (T2T) strategies,2 allowing access only to patients who remain with a disease activity Score-28 with erythrocite sedimentation rate (DAS28-ESR) >5.1 despite 6 months of treatment with three non-biological disease-modifying antirheumatic drugs (DMARDs) 3. Our results of the application of this law during the first year were recently published 4…”