Use of a validated quality of life questionnaire to assess sexual function following laparoscopic radical prostatectomy

Wagner, Andrew A.; Link, Richard E.; Pavlovich, Christian P.; Sullivan, Wendy; Su, Li-Ming

doi:10.1038/sj.ijir.3901376

Cited by 17 publications

(9 citation statements)

References 39 publications

(58 reference statements)

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“…Many more studies have used the EPIC to assess ED in prostate cancer patients. For example, outcomes after laparoscopic, 22 robot-assisted, 10 retropubic, 23 and perineal 24 radical prostatectomy have been reported based on the EPIC instrument. Similarly, the EPIC has been used to follow patients after external-beam radiotherapy or brachytherapy for prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Defining potency: A comparison of the International Index of Erectile Function short version and the Expanded Prostate Cancer Index Composite

Schroeck

Donatucci

Smathers

et al. 2008

Cancer

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BACKGROUND.Both the 5‐item short version of the International Index of Erectile Function (IIEF‐5) and the Expanded Prostate Cancer Index Composite (EPIC) have been used to assess erectile function. In this study, the authors compared various definitions of potency according to the IIEF‐5 and the EPIC.METHODS.Patients with prostate cancer who had completed the IIEF‐5 and the EPIC within 7 days of each other were included. The Spearman correlation coefficient (rho) was calculated to assess the relation between IIEF‐5 and EPIC sexual domain scores. Concordance of potency rates by IIEF‐5 and EPIC was assessed in cross‐tabulations. By calculating the area under the receiver operator characteristics (ROC) curve (AUC), the authors ascertained the discriminative ability of the IIEF‐5 score to identify potent men as defined by the EPIC.RESULTS.Analyzing 102 questionnaire pairs, IIEF‐5 and EPIC domain scores were found to be highly correlated (rho = 0.776). EPIC sexual domain scores ≥60 had high concordance with IIEF‐5 scores ≥17 (98%) and with nearly all single‐item definitions of potency (≥71%). However, an EPIC sexual domain score ≥80 was a very strict definition of potency, and only 54% of patients with IIEF‐5 scores ≥22 met this threshold. On the basis of ROC analysis (AUC = 0.90), an IIEF‐5 score ≥20 was identified as the ideal cutoff for defining potency and corresponded with an EPIC sexual domain score ≥60.CONCLUSIONS.IIEF‐5 and EPIC scores were highly correlated, but potency rates varied widely, depending on the definition of potency. The current results help with the interpretation of sexual function outcomes data in patients with prostate cancer. Cancer 2008. © 2008 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Defining potency: A comparison of the International Index of Erectile Function short version and the Expanded Prostate Cancer Index Composite

Schroeck

Donatucci

Smathers

et al. 2008

Cancer

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“…(16) EPIC has now been used in several studies to evaluate patient reported health-related QoL outcomes in the management of prostate cancer (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Intrarectal Amifostine During External Beam Radiation Therapy for Prostate Cancer Produces Significant Improvements in Quality of Life Measured by EPIC Score

Simone

Ménard

Soule

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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Purpose-To test whether intrarectal Amifostine limits symptoms of radiation proctitis as measured by the RTOG GI toxicity score and the expanded prostate cancer index composite (EPIC) score.Methods and Materials-Patients with localized prostate cancer recieved Amifostine as a rectal suspension 30-45 min before daily 3D-conformal radiation treatments (3D-CRT). The first 18 patients received 1gm of Amifostine and the next 12 patients received 2gm. Toxicity was assessed at baseline, during treatment, and at follow-up visits using RTOG grading and the EPIC Quality of Life (QoL) 50 item questionnaire. The "Bowel Function" subset of the bowel domain (EPIC-BF), which targets symptom severity, and "Bowel Bother" subset of the bowel domain (EPIC-BB), which assesses quality of life, were evaluated and compared to the RTOG GI toxicity score.Results-Median follow-up was 30 months (range 18-36). Overall, the EPIC-BF and EPIC-BB scores both track closely with the RTOG GI toxicity score. Seven weeks after the start of radiation therapy, the incidence of RTOG Grade 2 toxicity was 33% in the 1gm group (6/18) compared with 0% (0/12) in the 2gm group and trended towards statistical significance (p=0.06). A significant difference between Amifostine groups was observed using the EPIC-BF score at 7 weeks (p=0.04). A difference in EPIC-BB score between dose groups was evident at 7 weeks (p=0.07) and was significant at 12 months (p=0.04).

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“…Wagner et al [30] investigated the impact of nerve sparing during LRP on the sexual function of men using the EPIC questionnaire. The sexual function subscale score (SFSS) was reported as a percentage of baseline preoperative sexual function.…”

Section: Sexual Functionmentioning

confidence: 99%

Quality of Life after Radical Prostatectomy

2008

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Introduction: Radical prostatectomy is a standard approach to the management of prostate cancer. As the oncological outcome has improved, focus has drawn to the postoperative amelioration of health-related quality of life (HRQOL). Materials and Methods: The instruments that have already been used, or may be used, in assessing the HRQOL postoperatively in men with prostate cancer are presented. Results: Urinary and sexual dysfunction as well as fecal incontinence form the three possible major complications after surgery which affect the patient’s quality of life. Meticulous counseling regarding the potential morbidity associated with the operation that may affect the patient’s quality of life should be made before the patient gives his informed consent. Conclusions: Questionnaires only partially help to identify patients with dysfunction, especially sexual and bowel dysfunction, and careful patient counseling with their partners present is the best way to evaluate the presence of dysfunction pre- or postoperatively.

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Use of a validated quality of life questionnaire to assess sexual function following laparoscopic radical prostatectomy

Cited by 17 publications

References 39 publications

Defining potency: A comparison of the International Index of Erectile Function short version and the Expanded Prostate Cancer Index Composite

Defining potency: A comparison of the International Index of Erectile Function short version and the Expanded Prostate Cancer Index Composite

Intrarectal Amifostine During External Beam Radiation Therapy for Prostate Cancer Produces Significant Improvements in Quality of Life Measured by EPIC Score

Quality of Life after Radical Prostatectomy

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