2012
DOI: 10.1016/j.jss.2011.02.046
|View full text |Cite
|
Sign up to set email alerts
|

Use of a Third-Generation Perfluorocarbon for Preservation of Rat DCD Liver Grafts

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
16
0

Year Published

2012
2012
2022
2022

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 19 publications
(16 citation statements)
references
References 28 publications
0
16
0
Order By: Relevance
“…The results of the present study demonstrated that the oxygenation of DCD liver grafts provided by PFC attenuated liver IRI and improved the survival rate after DCD LT in the rat model. Although previous investigations found that PFCs can be beneficial with ex vivo reperfusion models, there have been no studies to date that investigated the effect of PFC using an in vivo DCD LT model. To the best of our knowledge, this would be the first study to investigate the impact of PFC on outcomes after DCD LT.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The results of the present study demonstrated that the oxygenation of DCD liver grafts provided by PFC attenuated liver IRI and improved the survival rate after DCD LT in the rat model. Although previous investigations found that PFCs can be beneficial with ex vivo reperfusion models, there have been no studies to date that investigated the effect of PFC using an in vivo DCD LT model. To the best of our knowledge, this would be the first study to investigate the impact of PFC on outcomes after DCD LT.…”
Section: Discussionmentioning
confidence: 99%
“…However, other previous experimental attempts in the liver and lung were not very convincing, possibly because of the structure, thickness, and density of these organs . The technical innovation of PFC emulsion allowed us to use this “hydrophobic” compound intravenously, and the recent generation of PFC emulsions has been proven useful in DCD liver graft preservation in ex vivo experimental models . The necessity of DCD liver graft oxygenation during cold preservation has also been recently revealed in hypothermic machine perfusion models .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Most groups recognize the need for a specialist oxygen carrier, although dissolving enough oxygen in a simple solution is theoretically possible using hyperbaric conditions . Specialist oxygen carriers that have been considered include perfluorocarbon molecules, but increasingly the consensus is to use erythrocytes. Blood‐based perfusates have been the basis of the majority of recent publications in this area .…”
Section: Implementations Of Normothermic Perfusion Of the Livermentioning
confidence: 99%
“…Perfluorocarbon (PFC) liquids have been investigated as a medical application for many years. These synthetic liquids are essentially bioinert and have no known deleterious histological, cellular, or biochemical effects [26,27,28,29,30]. The two-layer method (TLM) uses an oxygenated PFC and UW solution to preserve pancreases for whole organ and islet transplantation; TLM enhances pancreatic functions and increases islet cell yield after cold preservation compared with simple UW cold storage [25].…”
Section: Introductionmentioning
confidence: 99%