Use of a systematic review to inform the infection risk for biomedical engineers and technicians servicing biomedical devices

Smith, Anne-Louise

doi:10.1007/s13246-011-0103-3

Cited by 4 publications

(1 citation statement)

References 53 publications

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“…In order to improve the accuracy of medical treatment, flexible e-skin and implantable devices are widely applied in medical detection. Although these electronic devices can extend life span and promote living quality of the patients, they are also vulnerable to bacteria contamination. , According to the literature, the majority of biomedical devices have suffered from microbial contamination, which pose a risk to patients with weakened immune systems . The adhesion of material is considered as the major causes of biomedical device-associated infections .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Self-Adhesive, Recyclable, and Tough Conductive Composite Hydrogels for Ultrasensitive Strain Sensing

Fan

Xie

Zheng

et al. 2020

ACS Appl. Mater. Interfaces

143

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Owing to the characteristics of mimicking human skin's function and transmitting sensory signals, electronic skin (eskin), as an emerging and exciting research field, has inspired tremendous efforts in the biomedical field. However, it is frustrating that most e-skins are prone to bacterial infections, resulting a serious threat to human health. Therefore, the construction of e-skin with an integrated perceptual signal and antibacterial properties is highly desirable. Herein, the dynamic supramolecular hydrogel was prepared through a freezing/thawing method by cross-linking the conductive graphene (G), biocompatible polyvinyl alcohol (PVA), self-adhesive polydopamine (PDA), and in situ formation antibacterial silver nanoparticles (AgNPs). Having fabricated the hierarchical network structure, the PVA−G−PDA−AgNPs composite hydrogel with a tensile strength of 1.174 MPa and an elongation of 331% paves way for flexible e-skins. Notably, the PVA−G−PDA−AgNPs hydrogel exhibits outstanding antibacterial activity to typical pathogenic microbes (e.g., Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus), which effectively prevents bacterial infections that harm human health. With self-adhesiveness to various surfaces and excellent conductivity, the PVA−G−PDA−AgNPs composite hydrogel was used as strain sensors to detect a variety of macroscale and microscale human motions successfully. Meanwhile, the excellent rehealing property allows the hydrogel to recycle as a new sensor to detect large-scale human activities or tiny movement. Based on these remarkable features, the antibacterial, self-adhesive, recyclable, and tough conductive composite hydrogels possess the great promising application in biomedical materials.

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Section: Introductionmentioning

confidence: 99%

Antibacterial, Self-Adhesive, Recyclable, and Tough Conductive Composite Hydrogels for Ultrasensitive Strain Sensing

Fan

Xie

Zheng

et al. 2020

ACS Appl. Mater. Interfaces

143

View full text Add to dashboard Cite

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Autoclaving‐Derived Surface Coating with In Vitro and In Vivo Antimicrobial and Antibiofilm Efficacies

Zhi

Gao

et al. 2017

Adv Healthcare Materials

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Biomedical device-associated infections which engender severe threat to public health require feasible solutions. In this study, block copolymers consisting of antimicrobial, antifouling, and surface-tethering segments in one molecule are synthesized and grafted on polymeric substrates by a facile plasma/autoclave-assisted method. Hetero-bifunctional polyethylene glycol (PEG) with allyl and tosyl groups (APEG-OTs) is first prepared. PEGs with different molecular weights (1200 and 2400 Da) are employed. Polyhexamethylene guanidine (PHMG) which has excellent broad-spectrum antimicrobial activity and thermal/chemical stability, is conjugated with APEG-OTs to generate the block copolymer (APEG-PHMG). Allyl terminated PHMG (A-PHMG) without PEG segments is also synthesized by reacting PHMG with allyl glycidyl ether. The synthesized copolymers are thermal initiated by autoclaving and grafted on plasma pretreated silicone surface, forming permanently bonded bottlebrush-like coatings. Both A-PHMG and APEG -PHMG coatings exhibit potent antimicrobial activity against gram-positive/negative bacteria and fungus, whereas APEG -PHMG coatings show superior antifouling activity and long-term reusability to A-PHMG coating. APEG -PHMG coating demonstrates the most effective in vitro antibiofilm and protein/platelet-resistant properties, as well as excellent hemo/biocompatibility. Furthermore, APEG -PHMG greatly reduces the bacteria number with 5-log reduction in a rodent subcutaneous infection model. This rationally designed dual-functional antimicrobial and antifouling coating has great potential in combating biomedical devices/implant-associated infections.

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Substrate‐Independent Coating with Persistent and Stable Antifouling and Antibacterial Activities to Reduce Bacterial Infection for Various Implants

Yuan

Qiu

Wang

et al. 2019

Adv Healthcare Materials

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Implantation of biomedical devices accompanying infections has caused severe problems to public health that require feasible solutions. In this study, a simple approach is reported to fabricate a antimicrobial and antifouling dual‐functional coating. This coating consists of a substrate‐independent layer‐by‐layer (LBL) film formed by poly (diallyldimethylammonium) (PDDA) and poly (styrenesulfonate) (PSS), where parts of PSS and PDDA are physically substituted by hetero‐bifunctional polyethylene glycol (PEG) ending with a carboxyl group and antimicrobial peptide (ε‐Poly‐l‐lysine, ε‐PL). This design (ε‐PL‐PEG‐(PDDA/PSS)9 coating) exhibits not only potent antimicrobial activity against Gram‐positive/negative bacteria but also superior antifouling activity on various substrates, including glass and plastic. Moreover, the antifouling and antibacterial performance can be maintained for a longer period of time under physiological environments even after physical damage of the surface due to the homogeneous interspersion and free migration of ε‐PL‐PEG‐COOH in the LBL film. This allows the supplement of these molecules to the surface against molecule loss during usage. Both in vitro and in vivo (rodent subcutaneous infection model) studies show obvious reduction of the bacteria on the coated substrate and in the surrounding tissues with up to 3.2‐log reduction, even after repeated usage. The inflammation around the implantation area is also significantly inhibited.

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Use of a systematic review to inform the infection risk for biomedical engineers and technicians servicing biomedical devices

Cited by 4 publications

References 53 publications

Antibacterial, Self-Adhesive, Recyclable, and Tough Conductive Composite Hydrogels for Ultrasensitive Strain Sensing

Antibacterial, Self-Adhesive, Recyclable, and Tough Conductive Composite Hydrogels for Ultrasensitive Strain Sensing

Autoclaving‐Derived Surface Coating with In Vitro and In Vivo Antimicrobial and Antibiofilm Efficacies

Substrate‐Independent Coating with Persistent and Stable Antifouling and Antibacterial Activities to Reduce Bacterial Infection for Various Implants

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