Use of a static magnetic field to promote recovery after peripheral nerve injury

Kelleher, Michael O.; Al-Abri, Rashid; Lenihan, D. V.; Glasby, M. A.

doi:10.3171/jns.2006.105.4.610

Cited by 38 publications

(16 citation statements)

References 34 publications

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“…Moderate intensity static magnetic fields can induce changes in functioning of nervous, cardiovascular and reproductive systems (Okano and Ohkubo 2005;Ye et al 2008). Beside detrimental effects of electromagnetic radiation many studies point out the beneficial effects of the use of SMFs in medicine, from antinociceptive action to promotion of recovery of peripheral nerve injury, but the mechanism of action for achieving these effects is not completely known (Weintraub et al 2003;Kelleher et al 2006;Gyires et al 2008). As many diseases are associated with decreased activity of Na + /K + pump we could only speculate on the basis of our results that increased activity of pump mediated by 10 mT SMF could have a beneficial role.…”

Section: Discussionmentioning

confidence: 99%

Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension

Kesić

Nikolić²,

Savić³

et al. 2014

gpb

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Abstract. Aim of this study was to investigate the application of normalized mean of the empirical Higuchi fractal dimension (FD) distributions, as a new approach to analyze the spontaneous bioelectrical activity of garden snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of Br neuron bursting activity before and after the exposure to 10 mT static magnetic field (SMF) was observed by analyzing the following parameters: action potential (AP), interspike interval (ISI) and interbursting interval (IBI) components. Normalized mean of the empirical FD distributions were formed for the following experimental conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3, SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain without SMF induced increase in participation of AP and a decrease in participation of IBI components compared to the first control condition. However, in the presence of 10 mT SMF, ouabain-induced changes of measured parameters of Br neuron activity were less pronounced compared to the third control condition. We have shown that normalized mean of the empirical FD distributions is a useful method for detecting the changes in AP, ISI, and IBI components of complex bursting activity in altered physiological states.

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Section: Discussionmentioning

confidence: 99%

Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension

Kesić

Nikolić²,

Savić³

et al. 2014

gpb

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“…Numerous animal experiments have demonstrated that SMF could help promote the healing of various tissue defects, such as fresh and nonunion fracture, skin wound and ulcer, nerve injury, etc. [Darendeliler et al, 1997;Bertolino et al, 2006;Kelleher et al, 2006;Henry et al, 2008]. Several clinical investigations further confirmed the efficacy of SMF in impaired tissue repair and pain relief [Szor and Topp, 1998;Man et al, 1999;Trock, 2000].…”

Section: Introductionmentioning

confidence: 85%

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Jing

Shen

Cai

et al. 2010

Bioelectromagnetics

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Diabetic wound (DW) problems are becoming a formidable clinical challenge due to the sharp increase in the diabetic population and the high incidence of DW. Static magnetic field (SMF) therapy, an inexpensive and accessible noninvasive method, has been proven to be effective on various tissue repairs. However, the issue of the therapeutic effect of SMF on DW healing has never been investigated. The objective of this study was to systematically evaluate the effect of a 180 mT moderate-intensity gradient SMF on DW healing in streptozotocin-induced diabetic rats. Forty-eight 3-month-old male Sprague-Dawley rats (32 diabetic and 16 non-diabetic rats) were assigned to three equal groups: normal wound, DW, and DW + SMF groups. An open circular wound with 1.5 cm diameter was created in the dorsum. The wound was covered with a dressing and the magnet was fixed on top of the dressing. On days 5, 12, and 19, four rats of each group were euthanized and gross wound area, histology and tensile strength were evaluated. The wound area determination suggested that SMF significantly increased the healing rate and reduced the gross healing time. This result was further confirmed by histological observations. The wound tensile strength, reflecting the amount and quality of collagen deposition, increased to a larger extent in the DW + SMF group on days 12 and 19 compared with the DW group. The results indicated that 180 mT SMF presented a beneficial effect on DW healing, and implied the clinical potential of SMF therapy in accelerating DW repair and releasing the psychological and physical burdens of diabetic patients.

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“…Kelleher et al (2006) used this modality in sheep whose nerves were transected, an injury far more serious than the ''crush'' procedure used by most investigators. No difference was noted between magnet-treated nerves and sham controls.…”

Section: Discussionmentioning

confidence: 98%

“…Static magnetic fields have been tested on cultured cells (Teodori et al 2006) and animal preparations (Kelleher et al 2006) with varying measures of success. We began our studies using cultures of a chick embryo explant model of sensory neurons (Sisken et al 1984) since it is a classic system employed for studying neurobiological interactions and growth (Levi-Montalcini 1982, 2004.…”

Section: Introductionmentioning

confidence: 99%

Influence of static magnetic fields on nerve regeneration in vitro

et al. 2007

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Our research involves determining how noninvasive electric and magnetic fields influence neuronal growth in vitro. In previous studies we have shown that pulsed electromagnetic fields (PEMF) as well as direct current (DC) alone stimulate neurite outgrowth from dorsal root ganglion explants [Sisken et al. 1984; Sisken et al. (Restor Neurol Neurosci 1:303-309, 1990); Greenebaum et al. (Bioelectromagnetics 17:293-302, 1996)]. A maximum response was obtained when nerve growth factor (NGF) was also present in the medium. The results of our experiments using static magnetic fields of different strengths are presented below and indicate that fields of high magnetic strength (450-900 gauss) with added NGF stimulate neurite outgrowth comparable to the response obtained with PEMF plus NGF.

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Use of a static magnetic field to promote recovery after peripheral nerve injury

Abstract: Exogenously applied static electromagnetic fields do not enhance peripheral nerve regeneration.

Cited by 38 publications

References 34 publications

Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension

Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Influence of static magnetic fields on nerve regeneration in vitro

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