Use of a Standard Urine Assay for Measuring the Phosphate Content of Beverages

Lindley, Elizabeth; Costelloe, Seán; Bosomworth, M.; Fouque, Denis; Freeman, Julienne; Keane, David; Thompson, Douglas

doi:10.1053/j.jrn.2014.07.002

Cited by 12 publications

(9 citation statements)

References 6 publications

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“…In grape must, a common environment for yeast, phosphate availability is similar to that described in laboratory YPD medium (2.5 mM in YPD versus 3 mM in smashed grapes) (González Hermández et al ., ; Lindley et al ., ) In addition, yeast cells in nature are also subjected to sudden drastic environmental changes affecting nutrient availability. For this reason, the constant presence of a high Pi concentration in the laboratory may mask any eventual mechanisms disposed by cells to address nutrient scarcity.…”

Section: Discussionmentioning

confidence: 99%

Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae

Bru

Martínez-Láinez

Hernández-Ortega

et al. 2016

Molecular Microbiology

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Polyphosphate (polyP) is a linear chain of up to hundreds of inorganic phosphate residues that is necessary for many physiological functions in all living organisms. In some bacteria, polyP supplies material to molecules such as DNA, thus playing an important role in biosynthetic processes in prokaryotes. In the present study, we set out to gain further insight into the role of polyP in eukaryotic cells. We observed that polyP amounts are cyclically regulated in Saccharomyces cerevisiae, and those mutants that cannot synthesise (vtc4Δ) or hydrolyse polyP (ppn1Δ, ppx1Δ) present impaired cell cycle progression. Further analysis revealed that polyP mutants show delayed nucleotide production and increased genomic instability. Based on these findings, we concluded that polyP not only maintains intracellular phosphate concentrations in response to fluctuations in extracellular phosphate levels, but also muffles internal cyclic phosphate fluctuations, such as those produced by the sudden demand of phosphate to synthetize deoxynucleotides just before and during DNA duplication. We propose that the presence of polyP in eukaryotic cells is required for the timely and accurate duplication of DNA.

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Section: Discussionmentioning

confidence: 99%

Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae

Bru

Martínez-Láinez

Hernández-Ortega

et al. 2016

Molecular Microbiology

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“…This study indicates that the Pi content of these drinks actually had a limited impact on age related health. It should be noted, however that considerable amounts of Pi are also found in beer and wine [ 35 ] and this will need to be evaluated in more detail in pSoBid.…”

Section: Discussionmentioning

confidence: 99%

Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

McClelland

Christensen

Mohammed

et al. 2016

Aging

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BackgroundWe have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.ResultsWe observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.ConclusionsAccelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.

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“…18 This is, however, hampered by the increased costs of such products and by the reluctance of the food industry to adequately label the products for proper quantification. Reports such as that of Lindley et al 19 regarding phosphorus content in wine, beer, and soft drinks clearly illustrate this problem while appearing as an important encyclopedic resource to guide evidence-based patient recommendations.…”

mentioning

confidence: 99%

A Long Road to Travel: Adherence to Dietary Recommendations and Adequate Dietary Phosphorus Control

Carrero

Burrowes²,

Wanner

2016

Journal of Renal Nutrition

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Use of a Standard Urine Assay for Measuring the Phosphate Content of Beverages

Cited by 12 publications

References 6 publications

Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae

Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae

Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

A Long Road to Travel: Adherence to Dietary Recommendations and Adequate Dietary Phosphorus Control

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