Use of a Single Oral Dose of Doxycycline Monohydrate for Treating Gonorrheal Urethritis in Men

Treatment of gonorrhoea with single oral doses. Results obtained with doxycycline or rifampicin compared with intramuscular penicillin.

“…The results obtained with somewhat higher dosages (250 to 300 mg.) of doxycycline, as described by Sylvestre and Gallai (1968) and Domescik, McLone, Scotti, and Mackey (1969), while comparable with our results, are distinctly better (cure rate 94 to 95 per cent. compared to 88 per cent.).…”

A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

“…clomocycline) are under investigation (Oller, 1968), and also mixed preparations (Willcox, 1969) Doxycycline recently claimed to give 95 per cent. success with a single dose (Domescik, McLone, Scotti, and Mackey, 1969), as also methacycline (McLone, Billings, Lucas, Hardegree, and Hackney, 1968) Little used, but 90 to 96 per cent. cure rate reported with single oral doses (Greaves, Macdonald, Romansky, and Taggart, 1950;Tiedemann and others, 1962;Gjessing and Odegaard, 1967), and when combined with single injections of procaine penicillin (Gjessing and Odegaard, 1967) Its analogue, dextrosulphenidol, also effective (Table V) Analogue of chloramphenicol; methylsulphonyl group substituted for nitro group Less effective synthetic chloramphenicol-like substance Effective in multiple dosage (1-5 g. over one…”

Treatment of gonococcal urethritis with a single dose of doxycycline monohydrate.

“…In a study by Domescik, McLone, Scotti, and Mackey (1969), 95-3 per cent. of 158 males with uncomplicated gonorrhoea were cured by a single oral dose of 250 mg. doxycycline.…”