Use of a proximity extension proteomics assay to discover novel biomarkers associated with circulating leptin levels in two populations with type 2 diabetics
Abstract:Background We used a multiplex proteomics assay with the aim to discover novel associations between leptin and 88 circulating proteins in order to provide additional insights into the role of leptin in the development of CVD in patients with type 2 diabetes (T2DM). Material and methods In a discovery phase, we investigated associations between 88 plasma proteins, assessed with a proximity extension assay, and plasma leptin in a cohort of middle-aged patients with T2DM (CARDIPP, n=661). Associations that passed… Show more
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