Use of a new set of key performance indicators for evaluating the performance of an <i>in vitro</i> fertilization laboratory in which blastocyst culture and the freeze-all strategy are the primary treatment in patients with <i>in vitro</i> fertilization

HuiTian, Wang; Hong, Pingping; Li, Haiyang; Zhou, Wen; Li, Tao

doi:10.1177/03000605211044364

Cited by 3 publications

(2 citation statements)

References 36 publications

(61 reference statements)

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“…Therefore, it is standard procedure to reject these embryos after a fertilization check. When we assessed the studies published by Pirea et al , Variaelli et al , Zaca et al , Hammond et al , and Wang et al [9,10,11 ▪▪ ,15,16], we concluded that polyspermy rate was not considered an important KPI when compared to other evaluated PIs. Although many publications do not mention the number of PNs as a PI should be considered, as also mentioned in the Vienna Consensus, it can provide a marker of a problem in gamete handling or culture conditions and should be low under normal conditions.…”

Section: Technical Key Performance Indicators In Embryology Labmentioning

confidence: 89%

Embryology with precision: effective quality control in the in vitro fertilization laboratory

Basar,

Unsal,

Ergun

2024

Current Opinion in Obstetrics &Amp; Gynecology

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The purpose of this review is to address the critical need for standardization and clarity in the use of key performance indicators (KPIs) within the realm of in vitro fertilization (IVF), particularly emphasizing the integration of preimplantation genetic testing (PGT) processes. This review is timely and relevant given the persistently modest success rates of IVF treatments, which stand at approximately 30%, and the growing complexity of IVF procedures, including PGT practices. The review synthesizes recent findings across studies focusing on technical and clinical KPIs in embryology and genetic laboratories, identifying gaps in current research and practice, particularly the lack of standardized KPIs and terminology. Recent findings highlighted include the critical evaluation of technical KPIs such as Intracytoplasmic Sperm Injection (ICSI) fertilization rates, embryo development rates, and laboratory performance metrics, alongside clinical KPIs like the proportion of mature oocytes and clinical pregnancy rates. Notably, the review uncovers a significant gap in integrating and standardizing KPIs for PGT applications, which is essential for improving IVF outcomes and genetic diagnostic accuracy. The implications of these findings are profound for both clinical practice and research. For clinical practice, establishing a standardized set of KPIs, especially for PGT, could significantly enhance the success rates of IVF treatments by providing clearer benchmarks for quality and performance. For research, this review underscores the necessity for further studies to close the identified gaps, promoting a more integrated and standardized approach to KPIs in IVF and PGT processes. This comprehensive approach will not only aid in improving clinical outcomes but also in advancing the field of reproductive medicine.

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Section: Technical Key Performance Indicators In Embryology Labmentioning

confidence: 89%

Embryology with precision: effective quality control in the in vitro fertilization laboratory

Basar,

Unsal,

Ergun

2024

Current Opinion in Obstetrics &Amp; Gynecology

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“…This study provides overviews of current practice and important standards for creating KPIs. All 14 KPIs have benchmarks available [12].…”

Section: Types Of Artmentioning

confidence: 99%

Studying the IVF Laboratory Performance Indicators the Vienna Consensus 2017 for the High Institute According to Diagnosis and Assisted Reproductive for Infertility Technologies, Al-Nahrain University, Iraq

Hussein¹,

Rahim

Abdul-Hameed³

2022

Al-Kitab J. Pure Sci.

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Background: Performance indicators are used to assess patient safety, efficacy, equity, patient-centeredness, punctuality, and efficiency. The benchmark values for each Key Performance Indicator are aspirational values, and the minimum performance level values are the number of fertilized oocytes on Day 1 and the Normal Fertilization Rate, respectively (presence of 2Pro Nucleus and 2Polar Body measured at 17 h post-injection) as a Failed fertilization rate is calculated as the proportion of IVF cycles (excluding cycles with intracytoplasmic injection) on Day 1 (17 hours after insemination) with no signs of pregnancy. During fertilization (i.e., 0 oocytes with 2Pro Nucleus). The percentage of zygotes on Day 2 (44 hours after insemination) is known as the cleavage rate, and it can suggest an issue with sperm quality (sperm function, oocyte activation, and gamete receptors), sperm processing, or the quantity of spermatozoa used for insemination. which cleaves to create embryos. The percentage of cleaved embryos per successfully fertilized egg that are at the 4-cell stage on Day 2 (44 hours post-insemination) or at the 8-cell stage on Day 3 (68 hours post-insemination) is known as the embryo development rate. This evaluates the viability and quality of the embryos as well as the capacity of the culture system to promote cleavage at the necessary stages. The critical factor is the proportion of blastocysts observed at 116 hours after insemination as a function of the number of correctly fertilized oocytes. Measures of performance blastocyst development rate. The viability of the embryo as well as the culture system's capacity to support blastocyst formation from fertilized oocytes (i.e., the formation of an intracellular mass and a blastocoele cavity) are both determined by this factor. It should be noted that this phrase only considers blastocyst formation and not blastocyst stage or quality. The damage rate is the proportion of oocytes that are injured or have deteriorated by the time of fertilization assessment on Day 1 as a result of the intracytoplasmic injection. The percentage of biopsied and tubed/fixed samples where DNA is found represents the success rate of the biopsy. It serves as a gauge of the embryologists' ability to transfer biopsied samples to test tubes, as shown by successful DNA amplification. The number of gestational sacs divided by the total number of transplanted embryos is how one calculates the implantation rate, which is dependent on the cleavage stage. By dividing the number of gestational sacs by the total number of transplanted blastocysts, the implantation KPI (blastocyst stage) is calculated.

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Minimized microbial contamination rate in conventional IVF cycles after modifications of cumulus–oocyte complex handling

Hong

Zhou

et al. 2023

Reproductive BioMedicine Online

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Use of a new set of key performance indicators for evaluating the performance of an in vitro fertilization laboratory in which blastocyst culture and the freeze-all strategy are the primary treatment in patients with in vitro fertilization

Cited by 3 publications

References 36 publications

Embryology with precision: effective quality control in the in vitro fertilization laboratory

Embryology with precision: effective quality control in the in vitro fertilization laboratory

Studying the IVF Laboratory Performance Indicators the Vienna Consensus 2017 for the High Institute According to Diagnosis and Assisted Reproductive for Infertility Technologies, Al-Nahrain University, Iraq

Minimized microbial contamination rate in conventional IVF cycles after modifications of cumulus–oocyte complex handling

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