Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia

James, Andra H.; Lukes, Andrea S.; Brancazio, Leo R.; Thames, Elizabeth; Ortel, Thomas L.

doi:10.1016/j.ajog.2004.03.009

Cited by 42 publications

(34 citation statements)

References 19 publications

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“…In the last 13 years, it has also been established that bleeding disorders are more prevalent among women with menorrhagia. Among women with menorrhagia, the prevalence of von Willebrand disease (VWD) has been reported to be 5-20% [1][2][3][4][5][6][7] with an overall estimate of 13% [8] based on a systematic review. The prevalence of VWD and other bleeding disorders in women with menorrhagia is summarized in Table 2.…”

Section: Menorrhagia and Its Relationship To Bleeding Disordersmentioning

confidence: 99%

Women and bleeding disorders

James

2010

Haemophilia

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Summary. While women are rarely affected by haemophilia, they are equally as likely as men to have other bleeding disorders. Menorrhagia, or heavy menstrual bleeding, is the most common symptom that they experience. Not only is menorrhagia more prevalent among women with bleeding disorders, but bleeding disorders are more prevalent among women with menorrhagia. Although menorrhagia is the most common reproductive tract manifestation of a bleeding disorder, it is not the only manifestation. Women with bleeding disorders appear to be at an increased risk of developing haemorrhagic ovarian cysts and possibly endometriosis. Women suspected of having a bleeding disorder or being a carrier of haemophilia should be offered diagnostic testing before getting pregnant to allow for appropriate preconception counselling and pregnancy management. During pregnancy, women with bleeding disorders may be at an increased risk of bleeding complications. At the time of childbirth, women with bleeding disorders appear to be more likely to experience postpartum haemorrhage, particularly delayed or secondary postpartum haemorrhage. As women with bleeding disorders grow older, they may be more likely to manifest gynaecological conditions which present with bleeding. Women with bleeding disorders are more likely to undergo a hysterectomy and are more likely to have the operation at a younger age. While women with bleeding disorders are at risk for the same obstetrical and gynaecological problems that affect all women, women with bleeding disorders are disproportionately affected by conditions that manifest with bleeding. Optimal management involves the combined expertise of haemostasis experts and obstetrician-gynaecologists.

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Section: Menorrhagia and Its Relationship To Bleeding Disordersmentioning

confidence: 99%

Women and bleeding disorders

James

2010

Haemophilia

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“…While severe platelet defects are rare, mild platelet defects may affect up to one third of the general population. 6,7 Other bleeding disorders are rare and do not contribute to the overall prevalence of bleeding disorders. Immune thrombocytopenia purpura, an acquired disorder characterized by intermittent thrombocytopenia, is not a bleeding disorder except during periods of profound thrombocytopenia.…”

Section: Prevalence Of Bleeding Disordersmentioning

confidence: 99%

Obstetric Management of Adolescents with Bleeding Disorders

James¹

2010

Journal of Pediatric and Adolescent Gynecology

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“…1,2 Of women with the two most common bleeding disorders, von Willebrand disease (VWD) and platelet dysfunction, 32e100% complain of menorrhagia. 3,4 Other hematologic disorders associated with menorrhagia include Factor XI deficiency, hemophilia carrier states, and rare factor deficiencies.…”

mentioning

confidence: 99%

The Adolescent with Menorrhagia: Why, Who, and How to Evaluate for a Bleeding Disorder

Boswell

2011

Journal of Pediatric and Adolescent Gynecology

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Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia

Cited by 42 publications

References 19 publications

Women and bleeding disorders

Women and bleeding disorders

Obstetric Management of Adolescents with Bleeding Disorders

The Adolescent with Menorrhagia: Why, Who, and How to Evaluate for a Bleeding Disorder

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