Use of a long-acting GnRH agonist for benign cystic mesothelioma

Letterie, Gerard S.; Yon, Joseph L.

doi:10.1016/0029-7844(94)00431-c

Cited by 48 publications

(27 citation statements)

References 6 publications

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“…4 Conservative treatment includes longterm follow-up with or without the use of oral contraceptives to suppress ovulation, thus decreasing the formation of ovarian fluid trapped by adhesions. Gonadotropin-releasing hormone agonist therapy is another medical treatment recently proposed that can be integrated with sonographic follow-up, [23][24][25] used with the same rationale as with contraceptive pills. When the cyst is symptomatic, to reduce the risk of recurrence after open surgery, less invasive treatment than open surgery, such as sonographically guided fine-needle aspiration with or with-out ethanol instillation, followed or not by gonadotropin-releasing hormone agonist therapy, has been successfully proposed, also combined with sonographic diagnosis.…”

Section: Guerriero Et Almentioning

confidence: 99%

Role of Transvaginal Sonography in the Diagnosis of Peritoneal Inclusion Cysts

Guerriero

Ajossa

Mais

et al. 2004

Journal of Ultrasound in Medicine

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Objective. The aim of this prospective study was to investigate the accuracy of B-mode transvaginal sonography alone and combined with color Doppler imaging and cancer antigen 125 (CA 125) plasma concentrations in differentiating peritoneal cysts from other adnexal masses. Methods. Between September 1999 and September 2003, 213 adnexal masses underwent transvaginal sonography combined with power Doppler evaluation. Plasma concentrations of CA 125 were measured before surgery. The sonographic suspicion of peritoneal cysts (the presence of a bizarre lump-shaped cyst with a thin wall and fine internal septations with or without an ovary suspended among adhesions) was then compared with the surgical diagnosis. The overall agreement between the sonographic test results and the surgical findings was calculated by the κ index. The diagnostic value of each test was also evaluated with likelihood ratios (LRs). Results. Thirteen of 213 patients were found to have peritoneal cysts. Specificity and sensitivity of B-mode sonography for differentiating peritoneal cysts from other adnexal masses were 96% (95% confidence interval, 94%-97%) and 62% (95% confidence interval, 35%-83%), respectively. The value of the negative LR (0.40) indicated a good clinical test, whereas the positive LR (15) indicated an excellent test. Power Doppler imaging did not seem to increase the accuracy of B-mode transvaginal sonography (κ = 0.51 and 0.52, respectively), nor did the association of CA 125 plasma concentration (κ = 0.34). Conclusions. Transvaginal sonography alone is a useful method for detection of peritoneal cysts.

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Section: Guerriero Et Almentioning

confidence: 99%

Role of Transvaginal Sonography in the Diagnosis of Peritoneal Inclusion Cysts

Guerriero

Ajossa

Mais

et al. 2004

Journal of Ultrasound in Medicine

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“…15 The latter could be useful, particularly when a transformation into a malignant and potentially lethal lesion has been demonstrated. The use of leuprolide or tamoxifen have been suggested when BMPM expresses estrogen and progesterone receptors, 16,17 but as mentioned previously, the role of steroid receptor signaling in these tumors is still unknown. Rosen and Sutton 22 have proposed laparoscopic laser ablation with potassium titanyl phosphate as a potential treatment for the disease.…”

Section: Discussionmentioning

confidence: 95%

“…The use of the gonadotropin-releasing hormone agonist leuprolide and the antiestrogen agent tamoxifen has been reported to reduce cyst size, with a consequent relief in the distension-related symptoms. 16,17 Although Higuchi et al 18 demonstrated the presence of the mRNA for the estrogen, progesterone, and androgen receptors in samples of normal human pelvic peritoneum, the estrogen and progesterone receptor status has not yet been completely investigated. The true biological value of hormonal therapy for these tumors still remains unknown.…”

Section: Discussionmentioning

confidence: 98%

Cystic peritoneal mesothelioma: Report of a case

Cavallaro

Berretta²,

Menzo

et al. 2010

Surg Today

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Benign multicystic peritoneal mesothelioma (BMPM) is a rare disease with good short-term prognosis and rare malignant transformation. However, its biological significance remains unexplained. A neoplastic origin is considered by many authors to require a surgical excision, based on the high recurrence and progressive growth rate of the tumors. However, alternative or integrative treatment options have also been proposed. A 45-year-old woman presented to our unit with a history of occasional discomfort and pain in the left hip. On physical examination, we noticed a tough-elastic, fixed mass located in the iliac fossa. Computed tomography scan detected a mass with multiseptated cystic-like areas. Due to the similarity of these findings to a primitive sarcomatous tumor of the retroperitoneum, an arteriographic study was also performed. The patient underwent en bloc resection of the mass, including a segment of the sigmoid colon. The final pathologic diagnosis was cystic mesothelioma. Further studies are needed to better understand the etiology and pathogenesis of this rare disease, and to define a more tailored treatment plan.

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“…1 Transvaginal ultrasound demonstrated a multiloculated cyst size 61·40·55 mm 3 beside the normal left ovary sion cysts. These therapies include the use of tamoxifen [9], and a long-acting GnRH agonist [10]. The role of medical treatment in cases of symptomatic recurrent multiloculated peritoneal inclusion cysts is yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Sometimes this requires removal of attached organs such as ovaries, uterus or spleen [2]. Recurrences of multiloculated peritoneal inclusion cysts after resection have been well documented [3,[8][9][10]. Recently, new medical therapies have been made available for the treatment of recurrent multiloculated peritoneal inclu- Fig.…”

Section: Discussionmentioning

confidence: 99%

Multiloculated peritoneal inclusion cyst treated successfully with laparoscopic surgery

2005

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Background: Multiloculated peritoneal inclusion cysts or benign cystic mesotheliomas are most commonly found in women of reproductive years; the disease involves the abdomen, pelvis and retroperitoneum. Case: A 33-year-old, para 3-0-0-3, Thai woman presented to the hospital upon an incidental finding of left ovarian cyst and a mild pelvic pain for three months. Her pelvic examination revealed left ovarian cyst. Transvaginal ultrasonogram demonstrated a multiloculated cyst size 61·40·55 mm 3 adherent to the normal left ovary. Laparoscopic surgery was performed. There was a multiloculated cyst 6 cm in diameter in the left pelvic cavity. The cyst was excised and the histopathology revealed inclusion cysts. She was well at discharge and throughout the four-week and six-month follow-up periods. Conclusion: Although multiloculated peritoneal inclusion cyst is uncommon, it should be included in the differential diagnosis of adnexal masses. Surgical excision remains the current recommended treatment for symptomatic disease. Surgical excision by laparoscopy might be an alternative method for successful management.

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Use of a long-acting GnRH agonist for benign cystic mesothelioma

Abstract: Long-acting GnRH agonists may have a role in the conservative management of these rare neoplasms. The reduction in volume concomitant with a hypoestrogenic state and regrowth with addition of add-back therapy further suggest extreme sensitivity of this tumor to one or both hormones.

Cited by 48 publications

References 6 publications

Role of Transvaginal Sonography in the Diagnosis of Peritoneal Inclusion Cysts

Role of Transvaginal Sonography in the Diagnosis of Peritoneal Inclusion Cysts

Cystic peritoneal mesothelioma: Report of a case

Multiloculated peritoneal inclusion cyst treated successfully with laparoscopic surgery

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