Use of a fourth generation HIV assay for routine screening – The first year's experience

Fitzpatrick, Fidelma; Kaminski, G.; Jones, L.; Drudy, Ethna; Crean, Margaret

doi:10.1016/j.jinf.2006.01.007

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…In contrast, the AHI rate of 0.7% evaluated for determining cost-effectiveness in this study is not only more than 10 times higher than the AHI rate used in that previous study, but also in line with AHI rates reported previously for high risk individuals and MSM [30, 31]. While differing study populations may be the main explanation for differing findings [34], other factors such as lower costs for AHI tests in 2014 when compared to 2008 may provide additional explanation.…”

Section: Discussionsupporting

confidence: 81%

Screening for acute HIV infection in community-based settings: Cost-effectiveness and impact on transmissions

Hoenigl

Chaillon

Mehta

et al. 2016

Journal of Infection

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Objectives To determine cost-effectiveness of three community-based acute HIV infection (AHI) testing algorithms compared to HIV antibody testing alone by focusing on the potential of averting new infections occurring within a one-year time horizon among men who have sex with men (MSM). Methods Data sources for model parameters included actual cost and prevalence data derived from a community-based AHI screening program in San Diego, and published studies. Main outcome measure was costs per infection averted (IA). The lower end of the cost range of discounted lifetime costs of an HIV infection (i.e. $236,948) was used for defining cost-effectiveness. Results The most sensitive algorithm for AHI detection, which was based on HIV nucleic acid amplification testing, was estimated to prevent between 5 and 45 transmissions, with simulated costs per infection averted between $965 and $141,256 when compared to HIV antibody testing alone. Conclusion AHI testing was cost-effective in preventing new HIV infections among at risk MSM in San Diego, and also among other MSM populations with similar HIV prevalence but lower proportions of AHI diagnoses. These results indicate that community based AHI testing among MSM in the United States can pay for itself over the long run.

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Section: Discussionsupporting

confidence: 81%

Screening for acute HIV infection in community-based settings: Cost-effectiveness and impact on transmissions

Hoenigl

Chaillon

Mehta

et al. 2016

Journal of Infection

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“…A report from the National Virus Reference Laboratory, Dublin, Ireland [Fitzpatrick et al, 2006] evaluated 52,238 samples, collected over a period of a year, using the Murex HIV Ag/Ab combination assay. For urgent specimens, the AxSYM HIV Ag/Ab combination assay was used.…”

Section: S12mentioning

confidence: 99%

Early diagnosis of HIV infection

Devare

2007

J. Med. Virol.

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“…Nigeria is one of the greatest contributors to global paediatric HIV burden being responsible for about 30% of the global burden of MTCT of HIV infection (7,8,9) The factors responsible for the high burden of MTCT of HIV infection in Nigeria include: the high rates of HIV infection in women of reproductive age, high rate of fertility, mixed feeding of HIV exposed infants, poor access to health facilities for antenatal and delivery purposes and loss to follow-up of women living with HIV and HIV exposed infants (10).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Prevention of Mother to Child Transmission Programme at a Tertiary Healthcare Facility in Southwestern Nigeria

et al. 2023

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Most children acquire HIV infection as a result of mother to child transmission (MTCT). The risk of MTCT of HIV is generally estimated at between 15 and 40% without prophylaxis. MTCT was responsible for approximately 370,000 infant HIV infections worldwide with Nigeria accounting for 30%. The study evaluated the effectiveness of prevention of MTCT of HIV infection programme by determining the rate of MTCT of HIV in babies who underwent the programme by review of health records of mother-infant pairs at Olabisi Onabanjo University Teaching Hospital. This was a cross-sectional analytical conducted over twelve years period with medical records of 545 mother-infant pairs analysed. The rate of MTCT of HIV infection was 2.9% compared to 7.1% earlier reported in the centre. The rate of MTCT of HIV was lowest among mother-infant pairs who both received prophylaxis. Ages at recruitment are strong determinant of the risk of infection. Late usage of MTCT prevention service is a risk for HIV infection among exposed infants.

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Use of a fourth generation HIV assay for routine screening – The first year's experience

Cited by 6 publications

References 2 publications

Screening for acute HIV infection in community-based settings: Cost-effectiveness and impact on transmissions

Screening for acute HIV infection in community-based settings: Cost-effectiveness and impact on transmissions

Early diagnosis of HIV infection

Evaluation of Prevention of Mother to Child Transmission Programme at a Tertiary Healthcare Facility in Southwestern Nigeria

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