Use of a force-plate actometer for detecting and quantifying vertical leaping induced by amphetamine in BALB/cJ mice, but not in C57BL/6J, DBA/2J, 129X1/SvJ, C3H/HeJ, and CD-1 mice

McKerchar, Todd L.; Zarcone, Troy J.; Fowler, Stephen C.

doi:10.1016/j.jneumeth.2005.10.002

Cited by 15 publications

(13 citation statements)

References 24 publications

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“…In the course of measuring leaping behavior across the 5 treatment days, behavioral sensitization was seen in bouts of low mobility (a measure of spatial confinement due to focused stereotypy). However, the pattern of increase across treatment days did not differ significantly among the genotypes (McKerchar et al, 2006). Thus, genetic differences among these mouse genotypes did not influence magnitude of sensitization to the stereotypic effects of the drug.…”

Section: Inbred Strainsmentioning

confidence: 81%

“…Recently, a set of inbred strains has been characterized for vertical leaping behavior (sometimes called "popping," "jumping," or "hopping") induced by high dose d-amphetamine (10 mg/kg; McKerchar et al, 2006). The authors suggest that pharmacologically induced leaping behavior may be a relevant model for studying schizophrenia.…”

Section: Inbred Strainsmentioning

confidence: 99%

“…Whether or not to include vertical leaping among the stereotypic behaviors is not clear, but it does not appear to occur at lower acute doses of amphetamines Lal et al, 1975;. Among the 5 inbred strains and one outbred stock examined, only the BALB/cJ strain exhibited vertical leaping behavior in response to d-amphetamine (McKerchar et al, 2006). McKerchar et al (2006) describe some similarities in strain sensitivities to vertical leaping induced by d-amphetamine, dizocilpine (Deutsch et al, 1997) and naloxone-precipitated morphine withdrawal (Kest et al, 2002), although they point out the difficulty in making meaningful comparisons due to differences in dosing regimens and methods for quantification.…”

Section: Inbred Strainsmentioning

confidence: 99%

“…Among the 5 inbred strains and one outbred stock examined, only the BALB/cJ strain exhibited vertical leaping behavior in response to d-amphetamine (McKerchar et al, 2006). McKerchar et al (2006) describe some similarities in strain sensitivities to vertical leaping induced by d-amphetamine, dizocilpine (Deutsch et al, 1997) and naloxone-precipitated morphine withdrawal (Kest et al, 2002), although they point out the difficulty in making meaningful comparisons due to differences in dosing regimens and methods for quantification. In the course of measuring leaping behavior across the 5 treatment days, behavioral sensitization was seen in bouts of low mobility (a measure of spatial confinement due to focused stereotypy).…”

Section: Inbred Strainsmentioning

confidence: 99%

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Behavioral genetic contributions to the study of addiction-related amphetamine effects

Phillips

Kamens

Wheeler

2008

Neuroscience & Biobehavioral Reviews

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Amphetamines, including methamphetamine, pose a significant cost to society due to significant numbers of amphetamine-abusing individuals who suffer major health-related consequences. In addition, methamphetamine use is associated with heightened rates of violent and property-related crimes. The current paper reviews the existing literature addressing genetic differences in mice that impact behavioral responses thought to be relevant to the abuse of amphetamine and amphetaminelike drugs. Summarized are studies that used inbred strains, selected lines, single gene knockouts and transgenics, and quantitative trait locus (QTL) mapping populations. Acute sensitivity, neuroadaptive responses, rewarding and conditioned effects are among those reviewed. Some gene mapping work has been accomplished, and although no amphetamine-related complex trait genes have been definitively identified, translational work leading from results in the mouse to studies performed in humans is beginning to emerge. The majority of genetic investigations has utilized single-gene knockout mice and has concentrated on dopamine-and glutamate-related genes. Genes that code for cell support and signaling molecules are also well-represented. There is a large behavioral genetic literature on responsiveness to amphetamines, but a considerably smaller literature focused on genes that influence the development and acceleration of amphetamine use, withdrawal, relapse, and behavioral toxicity. Also missing are genetic investigations into the effects of amphetamines on social behaviors. This information might help to identify at-risk individuals and in the future to develop treatments that take advantage of individualized genetic information.

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Section: Inbred Strainsmentioning

confidence: 81%

Section: Inbred Strainsmentioning

confidence: 99%

Section: Inbred Strainsmentioning

confidence: 99%

Section: Inbred Strainsmentioning

confidence: 99%

See 2 more Smart Citations

Behavioral genetic contributions to the study of addiction-related amphetamine effects

Phillips

Kamens

Wheeler

2008

Neuroscience & Biobehavioral Reviews

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“…With spatial resolution of 1 mm and temporal resolution of 1 millisecond, the FPA tracks variations in power to quantify tremors ranging from 0.1 to 24.6 Hz (Fowler et al . 2001, 2002; McKerchar et al . 2006).…”

Section: Methodsmentioning

confidence: 99%

A single intramuscular injection of rAAV‐mediated mutant erythropoietin protects against MPTP‐induced parkinsonism

Dhanushkodi¹,

Akano²,

Roguski

et al. 2012

Genes Brain and Behavior

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Erythropoietin (Epo) is neuroprotective in a number of preparations, but can lead to unacceptably high and even lethal hematocrit levels. Recent reports show that modified Epo variants confer neuroprotection in models of glaucoma and retinal degeneration without raising hematocrit. In this study, neuroprotective effects of two Epo variants (EpoR76E and EpoS71E) were assessed in a model of Parkinson’s disease. The constructs were packaged in recombinant adeno-associated viral (rAAV) vectors and injected intramuscularly. After 3 weeks, mice received five daily injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and were killed 5 weeks later. The MPTP-lesioned mice pretreated with rAAV.eGFP (negative control) exhibited a 7- to 9-Hz tremor and slower latencies to move on a grid test (akinesia). Both of these symptomatic features were absent in mice pretreated with either modified Epo construct. The rAAV.eGFP-treated mice lesioned with MPTP exhibited a 41% reduction in tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. The rAAV.EpoS71E construct did not protect nigral neurons, but neuronal loss in mice pretreated with rAAV.EpoR76E was only half that of rAAV.eGFP controls. Although dopamine levels were normal in all groups, 3,4-dihydroxyphenylacetic acid (DOPAC) was significantly reduced only in MPTP-lesioned mice pre-treated with rAAV.eGFP, indicating reduced dopamine turnover. Analysis of TH-positive fibers in the striatum showed normalized density in MPTP-lesioned mice pretreated with rAAV.EpoS71E, suggesting that enhanced sprouting induced by EpoS71E may have been responsible for normal behavior and dopaminergic tone in these mice. These results show that systemically administered rAAV-generated non-erythropoietic Epo may protect against MPTP-induced parkinsonism by a combination of neuroprotection and enhanced axonal sprouting.

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The Role of Behavioural Toxicity in Risk Assessment

Weiss

2009

General, Applied and Systems Toxicology

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Behaviour is now established as a fundamental dimension of toxicity and risk assessment. It emerged as a criterion of adverse effects because many questions about health risks centred on measures such as IQ and other neuropsychological indices. Methylmercury and lead risks are quantified in such terms and clinical entities such as autism and attention deficit hyperactivity disorder are basically behavioural disorders. Behavioural methods, as a consequence, are essential research tools for determining the risks of exposure to environmental chemicals, for studying the mechanisms by which drugs act on nervous system diseases and for determining the potential of new pharmaceuticals to alter behaviour, either therapeutically or adversely. To fulfil these roles effectively, behavioural research must examine a variety of end points. These range from naturalistic behaviours, such as those involved in reproduction, to activity patterns, to motor and sensory function and to complex cognitive processes. At the same time, behavioural methods must encompass techniques applicable to both laboratory animals and humans.

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Use of a force-plate actometer for detecting and quantifying vertical leaping induced by amphetamine in BALB/cJ mice, but not in C57BL/6J, DBA/2J, 129X1/SvJ, C3H/HeJ, and CD-1 mice

Cited by 15 publications

References 24 publications

Behavioral genetic contributions to the study of addiction-related amphetamine effects

Behavioral genetic contributions to the study of addiction-related amphetamine effects

A single intramuscular injection of rAAV‐mediated mutant erythropoietin protects against MPTP‐induced parkinsonism

The Role of Behavioural Toxicity in Risk Assessment

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