Use of a Folic Acid Antagonist in Chronic Leukemia

Part VIII. Folic acid antagonists

“…Some activity of folic acid antagonists has been seen in chronic myelocytic leukemia by several authors, but the consensus is that remissions are short and inferior to those obtained with many other drugs." 59,164,165 A study of folic acid antagonists in lymphomas has recently been undertakent in an effort to see if chemotherapeutiC data from L-1210 lymphocytic neoplasm of mice""6 could serve as a useful prediction index. One can say at this time that amethopterin and dichloramethopterin have recognizable antitumor activity in lymphosarcoma and reticulum cell sarcoma.…”

Aminopterin in the Treatment of Acute Leukaemia

“…There is also, as the result of treatment, a profound fall in the numbers of mature granulocytes in the peripheral blood, presumably due to the destruction of their more primitive precursors. Normal lymphopoiesis does not seem to be so easily affected (Berman et al, 1949), but leukaemic lymphoblasts are undoubtedly susceptible (Dameshek, 1949). Thiersch (1949) has investigated the bone-marrow effects of aminopterin in man.…”