Abstract:581
Primary refractory or relapsed B-lineage acute lymphoblastic leukemia can be successfully treated by allogeneic stem cell transplantation (SCT). However, relapse remains still a major risk and will be significantly influenced by residual disease prior to or after SCT. In addition to standard chemotherapy, immunotherapeutic approaches are assumed to be able to reduce or clear persistent minimal disease. Here we investigated an Fc-optimized chimerized CD19 antibody on a compassionate use basis… Show more
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