Use of a Diuretic Combination of Triamterene and Hydrochlorothiazide in Elderly Patients

Bender, A. Douglas; Carter, Carolyn Lee; Hansen, Karl B.

doi:10.1111/j.1532-5415.1967.tb00714.x

Cited by 13 publications

(1 citation statement)

References 13 publications

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“…However, if the diastolic blood pressure persistently exceeds 105 mm Hg, methyldopa can be used with caution (41). A combination of triamterene and hydrochlorothiazide is a safe and effective diuretic agent for the treatment of edema (42).…”

Section: Drug Therapymentioning

confidence: 99%

Fluorescein Circulation Time and the Treatment of Hypertension in the Aged*

Fishback

1973

J American Geriatrics Society

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An objective test for circulation time was performed in rabbits with the use of various dyes, of which the best was 10% fluorescein. The average circulation time in rabbits was 5–6 seconds. Serum from hypertensive patients injected intravenously into rabbits usually prolonged the circulation time. Differences in the results based on the age of the patients indicated a more benign type of hypertension in the elderly. An outline is given of the treatment of hypertension in the aged. Many cases respond fairly well to reassurance, a low‐salt diet, and weight reduction when the patient is obese. If additional measures are needed, diuretics are effective, especially furosemide (40 mg once or twice daily). In moderate or severe hypertension with renal parenchymal disease and a high level of blood urea nitrogen, methyldopa (250 mg two to four times daily) is of value. Potassium supplements should be given along with diuretics. In the Philadelphia Geriatric Center there are 325 residents, nearly all between the ages of 70 and 100; and more than 140 of them have hypertension. There are about 100 cases of depression (present or past), 75 cases of hiatal hernia (some with ulcer), and 53 cases of peptic ulcer. Since reserpine can aggravate peptic ulcer and can precipitate or aggravate depression, it should not be used to treat hypertension in the aged; nor should guanethidine be used for this purpose, since it can cause weakness and cerebrovascular insufficiency. High blood pressure should be reduced slowly in the aged, to avoid untoward effects.

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Section: Drug Therapymentioning

confidence: 99%

Fluorescein Circulation Time and the Treatment of Hypertension in the Aged*

Fishback

1973

J American Geriatrics Society

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Fixed‐Dose Combination Diuretics in Congestive Heart Failure: An Evaluation

Levy

1979

The Journal of Clinical Pharma

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Thirty-two patients with congestive heart failure were studied for their clinical and biochemical responses to the administration of two combination diuretic products (hydrochlorothiazide/spironolactone and hydrochlorothiazide/triamterene) and the single entity diuretic furosemide. Data from these studies revealed the following: 1. Comparison of the patients on furosemide with those receiving the combination products showed no difference in serum potassium or 24-hour potassium excretion. 2. Significant changes in blood urea nitrogen, plasma renin activity, and urinary aldosterone excretion were noted with both fixed-combination medications but not with furosemide. 3. The combination diuretics offered no clinical benefits over the single agent furosemide. 4. Therapy is best served by the use of a single effective diuretic agent for the treatment of most patients with congestive heart failure.

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Fluid and Electrolyte Imbalance

MacLennan

Peden²

1989

Metabolic and Endocrine Problems in the Elderly

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Use of a Diuretic Combination of Triamterene and Hydrochlorothiazide in Elderly Patients

Cited by 13 publications

References 13 publications

Fluorescein Circulation Time and the Treatment of Hypertension in the Aged*

Fluorescein Circulation Time and the Treatment of Hypertension in the Aged*

Fixed‐Dose Combination Diuretics in Congestive Heart Failure: An Evaluation

Fluid and Electrolyte Imbalance

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