Use of a CMOS image sensor for beta-emitting radionuclide measurements

Solestizi, Luisa Alunni; Biasini, M.; Bocci, V.; Campeggi, C.; Capotosti, Amedeo; Collamati, Francesco; Faccini, R.; Fresch, P.; Giuliano, Lucia; Kanxheri, K.; Mancini‐Terracciano, C.; Mantini, S.; Marafini, M.; Meddi, F.; Morganti, S.; Mirabelli, R.; Camillocci, E. Solfaroli; Traini, G.; Servoli, L.

doi:10.1088/1748-0221/13/07/p07003

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…As far as we know, portable β − cameras have not been reported. That said, CMOS sensors have been suggested as relative simple detector for β − particle imaging, without the need for a scintillation material [165].…”

Section: Background and Recent Advances Similar As Whatmentioning

confidence: 99%

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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Introduction: Radioguided surgery is an ever-evolving part of nuclear medicine. In fact, this nuclear medicine sub-discipline actively bridges non-invasive molecular imaging with surgical care. Next to relying on the availability of radio-and bimodal-tracers, the success of radioguided surgery is for a large part dependent on the imaging modalities and imaging concepts available for the surgical setting. With this review, we have aimed to provide a comprehensive update of the most recent advances in the field. Areas covered: We have made an attempt to cover all aspects of radioguided surgery: 1) the use of radioisotopes that emit γ, β + , and/or β − radiation, 2) hardware developments ranging from probes to 2D cameras and even the use of advanced 3D interventional imaging solutions, and 3) multiplexing solutions such as dual-isotope detection or combined radionuclear and optical detection. Expert opinion: Technical refinements in the field of radioguided surgery should continue to focus on supporting its implementation in the increasingly complex minimally invasive surgical setting, e.g. by accommodating robot-assisted laparoscopic surgery. In addition, hybrid concepts that integrate the use of radioisotopes with other image-guided surgery modalities such as fluorescence or ultrasound are likely to expand in the future.

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Section: Background and Recent Advances Similar As Whatmentioning

confidence: 99%

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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show abstract

“…For this reason, only pixels with 𝑆 𝑘 𝑖 𝑗 above a given threshold are preserved and written in a "reduced" file. This file is then analyzed to find clusters by means of the procedure described in [20], giving finally a count of particles per frame interacting in the detector [21].…”

Section: Data Analysis Algorithmmentioning

confidence: 99%

“…Since a particularly important aspect is the stability of the detector's response, a dedicated series of measurements have been performed to study its behaviour as a function of temperature, time, gain and integration time. Starting values for the scans are those used in a previous work [20], i.e. nominal gain = 1 (absolute gain = 1.31), integration time = 200 ms, true black value of 42.…”

Section: Stabilitymentioning

confidence: 99%

“…They can be caused by many reasons: high leakage current, circuit defects, dust particles, scratches. Since their presence can alter the particle count, the algorithm identifies and removes them, as detailed in [20].…”

Section: True Black Level and Gainmentioning

confidence: 99%

“…As far as pedestals (figure 6a) and noise (figure 6b) are concerned, variations at 1% level are found, demonstrating their good stability. The clustering algorithm defined in [20] allows to group together pixels belonging to the same electron interaction with the sensor. The distribution of cluster width in terms of number of pixels is reported in figure 6c, where the shape is the expected one.…”

Section: Integration Timementioning

confidence: 99%

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Stability and efficiency of a CMOS sensor as detector of low energy β and γ particles

Collamati¹,

Amoruso²,

Servoli³

et al. 2020

J. Inst.

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First-in-human validation of a DROP-IN β-probe for robotic radioguided surgery: defining optimal signal-to-background discrimination algorithm

Collamati,

Morganti,

van Oosterom

et al. 2024

Eur J Nucl Med Mol Imaging

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Purpose In radioguided surgery (RGS), radiopharmaceuticals are used to generate preoperative roadmaps (e.g., PET/CT) and to facilitate intraoperative tracing of tracer avid lesions. Within RGS, there is a push toward the use of receptor-targeted radiopharmaceuticals, a trend that also has to align with the surgical move toward minimal invasive robotic surgery. Building on our initial ex vivo evaluation, this study investigates the clinical translation of a DROP-IN β probe in robotic PSMA-guided prostate cancer surgery. Methods A clinical-grade DROP-IN β probe was developed to support the detection of PET radioisotopes (e.g., 68 Ga). The prototype was evaluated in 7 primary prostate cancer patients, having at least 1 lymph node metastases visible on PSMA-PET. Patients were scheduled for radical prostatectomy combined with extended pelvic lymph node dissection. At the beginning of surgery, patients were injected with 1.1 MBq/kg of [68Ga]Ga-PSMA. The β probe was used to trace PSMA-expressing lymph nodes in vivo. To support intraoperative decision-making, a statistical software algorithm was defined and optimized on this dataset to help the surgeon discriminate between probe signals coming from tumors and healthy tissue. Results The DROP-IN β probe helped provide the surgeon with autonomous and highly maneuverable tracer detection. A total of 66 samples (i.e., lymph node specimens) were analyzed in vivo, of which 31 (47%) were found to be malignant. After optimization of the signal cutoff algorithm, we found a probe detection rate of 78% of the PSMA-PET-positive samples, a sensitivity of 76%, and a specificity of 93%, as compared to pathologic evaluation. Conclusion This study shows the first-in-human use of a DROP-IN β probe, supporting the integration of β radio guidance and robotic surgery. The achieved competitive sensitivity and specificity help open the world of robotic RGS to a whole new range of radiopharmaceuticals.

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Use of a CMOS image sensor for beta-emitting radionuclide measurements

Cited by 7 publications

References 25 publications

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Stability and efficiency of a CMOS sensor as detector of low energy β and γ particles

First-in-human validation of a DROP-IN β-probe for robotic radioguided surgery: defining optimal signal-to-background discrimination algorithm

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